Search for dissertations about: "methylation"

Showing result 16 - 20 of 381 swedish dissertations containing the word methylation.

  2. 16. CTCF and Epigenetic Regulation of the H19/Igf2 Locus

    Author : Vinod Pant; Rolf Ohlsson; Rainer Reinkawitz; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; Imprinting; Chromatin; H19; Igf2; CTCF; Insulator; methylation; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : An overall coordination between the expressions of genes is required for the proper development of an individual. Although most genes are expressed from both the constituent alleles of the genome, a small subset of autosomal genes are preferentially expressed from only one of the parental alleles, a phenomenon known as genomic imprinting. READ MORE

  4. 17. N-Heterocyclic Carbene-Phosphine Iridium Catalyzed Alkylation Reactions and Asymmetric Hydrogenation of Ketones

    Author : Sutthichat Kerdphon; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; C-C coupling reactions; hydrogen transfer; iridium; ketones; methylation;

    Abstract : This thesis is focused on hydrogen transfer reactions using N-heterocyclic carbenephosphine iridium catalysts and is divided in two parts. The first part describes the use of achiral N-heterocyclic carbene-phosphine iridium complexes catalyzing the methylation of ketones and alkylation of amides using alcohols as the electrophile. READ MORE

  5. 18. Mercury species transformations in marine and biological systems studied by isotope dilution mass spectrometry and stable isotope tracers

    Author : Lars Lambertsson; Wolfgang Frech; John Munthe; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Analytical chemistry; Mercury; methylmercury; ethylmercury; Thimerosal; speciation; methylation; demethylation; brackish water sediment; natural waters; GC-ICP-MS; species-specific isotope dilution; isotope enriched tracers; Analytisk kemi; Analytical chemistry; Analytisk kemi; analytisk kemi; Analytical Chemistry;

    Abstract : This thesis focuses on the implementation of species-specific isotope dilution (SSID) methodology and stable isotope tracers to determine mercury species occurrence and transformation processes in-situ and during sample treatment. Isotope enriched tracers of methyl-, ethyl- and inorganic mercury were synthesised and applied in different combinations to marine and biological samples. READ MORE

  6. 19. Molecular Signatures of Cancer

    Author : Esther Edlundh-Rose; Joakim Lundeberg; Peter Södervist; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; : BRAF; NRAS; MGMT; methylation; pyrosequencing; microarray technology; gene expression analysis; Molecular biology; Molekylärbiologi;

    Abstract : Cancer is an important public health concern in the western world, responsible for around 25% of all deaths. Although improvements have been made in the diagnosis of cancer, treatment of disseminated disease is inefficient, highlighting the need for new and improved methods of diagnosis and therapy. READ MORE

  7. 20. Genetics, epigenetics and functional mechanisms in inherited corneal and retinal dystrophies

    Author : Ida Maria Westin; Irina Golovleva; Berit Byström; Marie Burstedt; Ola Sandgren; Sudha Iyengar; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Genetics; Epigenetics; Splicing; Methylation; Ophtalmology; FECD; Stargardt; Retinitis pigmentosa; ABCA4; EYS; TCF4; F5; THBD; Coagulation factor V; Thrombomodulin; medicinsk genetik; Medical Genetics;

    Abstract : Inherited eye disorders (IED) are groups of genetically and clinically heterogenous conditions affecting different tissues in the eye. IED are most often progressive with reduced vision or legal blindness as outcome. READ MORE