Search for dissertations about: "methyltransferase"

Showing result 6 - 10 of 85 swedish dissertations containing the word methyltransferase.

  2. 6. Biophysical Characterization of Thiopurine S-Methyltransferase : A Key enzyme in the Effects of Thiopurine Drugs

    Author : Patricia Wennerstrand; Lars-Göran Mårtensson; Curt Peterson; Malin Lindqvist Appell; Mikael Widersten; Linköpings universitet; []
    Keywords : ;

    Abstract : In the treatment of leukemia and inflammatory bowel disease, thiopurines are commonly used drugs. Thiopurine S-methyltransferase (TPMT) is one of the drug metabolizing enzymes responsible of counteracting the formation of TGNs that will be incorporated into the DNA and RNA synthesis and thus induce apoptosis. READ MORE

  4. 7. Catechol-o-methyltransferase activity in human erythrocytes : a methodological and genetic investigation

    Author : Ylva Floderus; Uppsala universitet; []
    Keywords : MEDICINE; MEDICIN;

    Abstract : .... READ MORE

  5. 8. Thiopurine S-methyltransferase - characterization of variants and ligand binding

    Author : Annica Blissing; Lars-Göran Mårtensson; Tomas Nyman; Linköpings universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; NATURVETENSKAP; NATURAL SCIENCES; Thiopurine S-methyltransferase TPMT ; protein stability; enzyme kinetics; ligand binding; isothermal titration calorimetry ITC ; 8-anilinonaphthalene-1-sulfonic acid ANS ;

    Abstract : Thiopurine S-methyltransferase (TPMT) belongs to the Class I S-adenosylmethionine-dependent methyltransferase (SAM-MT) super family of structurally related proteins. Common to the members of this large protein family is the catalysis of methylation reactions using S-adenosylmethionine (SAM) as a methyl group donor, although SAM-MTs act on a wide range of different substrates and carry out numerous biologically important functions. READ MORE

  6. 9. Methyltransferase Ash1, histone methylation and their impact on Polycomb repression

    Author : Eshagh Dorafshan Esfahani; Yuri B. Schwartz; Jan Larsson; Dale Dorsett; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Trithorax Group proteins; Polycomb Group proteins; PRC1; PRC2; PRE; histone methylation; histone ubiquitylation; Ash1; SET domain; H3K36; H3K27; Drosophila;

    Abstract : Antagonistic interactions between Polycomb Group (PcG) and Trithorax Group (TrxG) proteins orchestrate the expression of key developmental genes. Distinct maternally loaded repressors establish the silenced state of these genes in cells where they should not be expressed and later PcG proteins sense whether a target gene is inactive and maintain the repression throughout multiple cell divisions. READ MORE

  7. 10. Clinical studies of thiopurine metabolism in inflammatory bowel disease

    Author : Ulf Hindorf; Lund Medicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Gastroenterologi; Gastro-enterology; thiopurine methyltransferase; 6-mercaptopurine; azathioprine; Inflammatory bowel disease; thiopurines; adverse events; methylated metabolites; thioguanine nucleotides;

    Abstract : Inflammatory bowel disease (IBD, i.e. primarily Crohn's disease and ulcerative colitis) is characterised by a chronic or relapsing inflammation of the digestive tract. READ MORE