Search for dissertations about: "mevalonate"
Showing result 6 - 10 of 29 swedish dissertations containing the word mevalonate.
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6. Requirement for mevalonate-derived lipids in cell proliferation : a study of the role of polyisoprenoid alcohols
Abstract : Mevalonic acid constitutes a key intermediate in the biosynthesis of a number of isoprenoid products. These metabolites include cholesterol and sterol-derived molecules, but also a large number of non-sterol isoprene derivatives. READ MORE
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7. In vitro studies on the biosynthesis and reduction of ubiquinone
Abstract : This thesis concerns the role of ubiquinone, the only endogenously synthesised lipid soluble antioxidant, in the cellular defence against peroxidation of proteins and lipids. The aims of the present investigations were to study the biosynthesis of ubiquinone in two different organelle fractions, i.e. READ MORE
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8. Studies on the regulatory roles of cholesterol and bile acids
Abstract : Cholesterol is essential for normal growth and development in mammals. However, excess cholesterol can be harmful leading to diseases such as atherosclerosis and gallstones. Once formed the ring structure of cholesterol cannot be catabolised by the body and must therefore be converted to other compounds for excretion. READ MORE
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9. Studies on N-linked glycosylation in proliferation and viability of normal and tumor cells in vitro
Abstract : A number of studies suggest a critical role of N-linked glycosylation for cellular proliferation. In addition, many transformed and tumor cells have an altered 3-hydroxy-3-methylglutaryl coenzyme A (HMG-CoA) reductase activity and an increased N-linked glycosylation. READ MORE
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10. High-throughput screening using multicellular tumor spheroids to reveal and exploit tumor-specific vulnerabilities
Abstract : High-throughput drug screening (HTS) in live cells is often a vital part of the preclinical anticancer drug discovery process. So far, two-dimensional (2D) monolayer cell cultures have been the most prevalent model in HTS endeavors. However, 2D cell cultures often fail to recapitulate the complex microenvironments of in vivo tumors. READ MORE