Search for dissertations about: "mhc-ii"

Showing result 1 - 5 of 35 swedish dissertations containing the word mhc-ii.

  2. 1. Positional identification and functional analysis of genes regulating autoimmune arthritis

    Author : Anthony Chun Yeung Yau; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The major histocompatibility complex (MHC) is the most gene-dense and polymorphic region in the human genome with strong associations to many autoimmune disorders, including rheumatoid arthritis (RA). However, even the genetic association between MHC and RA was known more than 40 years ago, we still have not fully explained the functional roles of the MHC genes and identified the underlying specific polymorphisms. READ MORE

  4. 2. Binding Kinetics of Proteins at Immune-Cell Contacts

    Author : Manto Chouliara; NanoLund: Centre for Nanoscience; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; T cells; Binding Kinetics; Affinity; Lifetime; CD4; CD2; TIRF Microscopy; SLBs;

    Abstract : Protein-protein interactions are crucial in numerous cellular functions and biological processes that take place inside our body. It is therefore not surprising that these interactions also govern the response of our body´s defence mechanism, the so-called immune system, towards an infection. READ MORE

  5. 3. Immunopathological aspects of equine inflammatory bowel disease

    Author : Karin Olofsson; Sveriges lantbruksuniversitet; Sveriges lantbruksuniversitet; []
    Keywords : LANTBRUKSVETENSKAPER; AGRICULTURAL SCIENCES;

    Abstract : Intestinal inflammation is a major welfare issue for horses causing colic, diarrhoea and an inability to thrive. One of the diagnoses with poor prognosis is inflammatory bowel disease (eqIBD). READ MORE

  6. 4. Studying the influence of the physicochemical properties of lipid nanoparticles for mucosal vaccine delivery

    Author : Karin Norling; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; influenza; nanoparticles; CTA1-DD; liposomes; dendritic cells; lipodisks; antigen presentation; flow cytometry; vaccine carriers; TIRF microscopy;

    Abstract : Lipid-based nanoparticles have attracted attention as promising pharmaceutical carriers. Reports of them having inherent adjuvant properties make them particularly interesting as vaccine vectors; however, the physicochemical profile of an ideal nanoparticle for mucosal vaccine delivery remains unknown. READ MORE

  7. 5. The importance of major histocompatibility complex class II genes for the development of autoimmune inflammation

    Author : Ulrica Brunsberg; Immunologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; transplantation; serology; Immunology; Mhc polymorphism arthritis evolution; Immunologi; serologi;

    Abstract : In this thesis the role of major histocompatibility complex (Mhc) class II molecules in development of autoimmune disease such as rheumatoid arthritis (RA), was studied. By combining an experimental model for RA, collagen type II induced arthritis (CIA), with molecular biology methods the importance of polymorphism in Mhc class II genes for disease development was investigated. READ MORE