Search for dissertations about: "mianserin"
Found 3 swedish dissertations containing the word mianserin.
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1. Enantioselective drug metabolism catalysed by the polymorphic CYP2D6 and CYP2C19 : a methodological investigation focused on mianserin, mephenytoin and omeprazole
Abstract : The aim of this thesis was to develop enantioselective analytical methods and apply them to studies of oxidative metabolism of chiral drugs catalysed by the polymorphic cytochrome P450 CYP2D6 and CYP2C 19 enzymes. The work has been focused on mianserin, mephenytoin and omeprazole. READ MORE
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2. Cytochrome P450 in the rat brain : characterization and regulation
Abstract : Cytochrome P450s (CYPs) are key enzymes in the metabolism of cholesterol and fatty acids and their derivatives in the body. In the adrenals and gonads these enzymes are involved in steroid hormone biosynthesis, in the liver in bile acid synthesis, in the kidney in synthesis of the calcitropic hormone, calcitriol, and in the cardiovascular system in synthesis of thromboxane A2, a potent inducer of vasoconstriction and platelet aggregation. READ MORE
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3. Novel pharmacological treatment alternatives for schizophrenia
Abstract : Antipsychotic drugs are commonly divided into typical (first generation) and atypical (second generation) antipsychotic drugs. Clinically effective doses of typical antipsychotic drugs generate a striatal dopamine D2 receptor occupancy of about 70 80%, approaching a level that is associated with a high risk of extrapyramidal side effects. READ MORE