Search for dissertations about: "mice 2014"

Showing result 1 - 5 of 122 swedish dissertations containing the words mice 2014.

2. 1. Site-specific labeling of affinity molecules for in vitro and in vivo studies

   Author : Anna Perols; Amelie Eriksson Karlström; Christian Hackenberger; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Affibody molecules; molecular imaging; site-specific labeling; solid phase peptide synthesis; IgG-binding domains; photoconjugation.; Bioteknologi; Biotechnology;

   Abstract : The thesis is focused on site-specific labeling of affinity molecules for different applications where two types of binding proteins, Affibody molecules and antibodies, have been used. For the purpose of improving the properties of Affibody molecules for in vivo imaging, novel bi-functional chelators for radiolabeling using the radionuclide 111In were evaluated. READ MORE

4. 2. Protein expression and modifications in denervated atrophic and hypertrophic skeletal muscle

   Author : Kim Evertsson; Sven Tågerud; Håkan Westerblad; Linnéuniversitetet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Skeletal muscle; denervation; atrophy; hypertrophy; protein expression; protein phosphorylation; Akt; p38; MK2; Hsp25; Hsp70; FoxO1; MuRF1; autophagy; Lamp1; Lc3; Biomedical Sciences; Biomedicinsk vetenskap;

   Abstract : Skeletal muscle comprises about 45% of the total body weight. It is the largest tissue in the body, vital for maintaining posture, produce locomotion, breathing but also functions as a large reservoir of proteins. READ MORE

5. 3. Development of Novel Models for Studying Osteoclasts

   Author : Christian Thudium; Avdelningen för molekylärmedicin och genterapi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Osteoclast; Osteopetrosis; Osteoporosis; Bone; Hematopoiesis; Gene Therapy; Mouse Models; oc oc; RANK KO;

   Abstract : This thesis focuses on developing and characterizing novel models for studying osteoclasts with an emphasis on how mutations abolishing osteoclastic acidification affect osteoclast signaling and bone remodeling, as well as how to treat patients bearing these rare mutations. Bone remodeling is under normal circumstances a tightly balanced process where resorption of bone by osteoclasts is followed by adequate amounts of bone formation by osteoblasts. READ MORE

6. 4. The role of CysLT1R in animal models of colorectal cancer

   Author : Sayeh Savari; Malmö Cellpatologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

   Abstract : Cysteinyl leukotrienes (LTC4, LTD4 and LTE4) are potent pro-inflammatory lipids derived from arachidonic acid and mediate their effect through CysLT1R and CysLT2R. There is a strong correlation between long-standing inflammatory bowel disease where these pro-inflammatory mediators are abundant and colorectal cancer. READ MORE

7. 5. CD47–SIRPα : an interaction of importance for bone cell differentiation

   Author : Cecilia Koskinen; Pernilla Lundberg; Per-Arne Oldenborg; Riku Kiviranta; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; CD47; SIRPalpha; osteoblast; osteoclast; SHP-2; Akt2; cell research; cellforskning;

   Abstract : Bone tissue is continuously remodeled by bone-forming osteoblasts and bone-resorbing osteoclasts, in processes tightly regulated by hormones, cytokines and growth factors. CD47, a ubiquitously expressed protein, and one of its ligands, signal-regulatory protein alpha (SIRPα), are two cell-surface proteins belonging to the immunoglobulin (Ig)-superfamily. READ MORE