Search for dissertations about: "mice and Alzheimer s"

Showing result 1 - 5 of 14 swedish dissertations containing the words mice and Alzheimer s.

  1. 1. Effects of Alzheimer s and Parkinson s disease gene mutation on cell signaling

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Nodi Dehvari; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Alzheimer s disease (AD) and Parkinson s disease (PD) are the major neurodegenerative disorders affecting the elderly. The discovery of genes causing familial forms of these disorders has contributed enormously towards our understanding of underlying pathogenic mechanisms. READ MORE

  2. 2. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer s disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Daniel Famer; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer s disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE

  3. 3. Stem cell differentiation, plasticity and regenerative mechanisms in the cholinergic system : Implications for Alzheimer´s disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Mats Nilbratt; Karolinska Institutet.; Karolinska Institutet.; [2008]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer´s disease; amyloid precursor protein; cholinergic differentiation; human embryonic stem cells; neural precursor; nicotinic acetylcholine receptor; neurotrophic factor; radial glial cells; transplantation;

    Abstract : Stem cells are immature cells with self-renewal capacity. They are able to differentiate into multiple lineages that may serve as a source of expandable cells for various applications. READ MORE

  4. 4. Regulatory mechanisms and plasticity of nicotinic receptors in transgenic mice overexpressing human beta-amyloid (APPswe) and acetylcholinesterase : Implications for Alzheimer´s disease

    University dissertation from Stockholm : Karolinska Institutet, Department of Clinical Neuroscience, Occupational Therapy and Elderly Care Research (NEUROTEC)

    Author : Marie M Svedberg; Karolinska Institutet.; Karolinska Institutet.; [2005]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Alzheimer's disease (AD) is the most frequent type of dementia and is characterized neuropathologically by deposition of plaques containing beta-amyloid (Abeta) and by neurofibrillary tangles, of which the main component is hyperphosphorylated tau. The degenerative progression seen in AD is accompanied by disturbances in several neurotransmitter systems, especially the cholinergic neurotransmitter system. READ MORE

  5. 5. Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer s disease-related mouse models : Interactive mechanisms with focus on new drug targets

    University dissertation from Stockholm : Karolinska Institutet, Department of Neurobiology, Care Sciences and Society

    Author : Monika M Hedberg; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Accumulation of beta-amyloid (Abeta), neuronal loss and changes in neurotransmitter systems, in particular the cholinergic system, are consistent features of Alzheimer s disease (AD). Abeta is thought to play a critical role in the pathogenesis of AD and it has therefore become a target of interest as regards a therapeutic approach. READ MORE