Search for dissertations about: "mice models Alzheimer"

Showing result 1 - 5 of 8 swedish dissertations containing the words mice models Alzheimer.

2. 1. Automated behavioral phenotyping of inbred mouse strains and mouse models of Alzheimer disease

   Author : Alina Codita; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Behavioral characterization of various mouse strains created as models for human diseases such as Alzheimer disease requires robust phenotyping methods. Previous work on inbred mouse strains has shown that some of the widely used behavioral methods yield inconsistent results across laboratories, in spite of standardization efforts. READ MORE

4. 2. The Mitochondrial Peptidasome, PreP, relation to Alzheimer Disease

   Author : Nyosha Alikhani; Elzbieta Glaser; Doron Rapaport; Stockholms universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Amyloid-β (Aβ) is the toxic peptide implicated in the pathogenesis of Alzheimer Disease (AD). Accumulation of Aβ has been shown in brain mitochondria from AD patients and AD mice models. The occurrence of Aβ in the mitochondrial matrix leads to free radical generation and apoptosis in neurons. READ MORE

5. 3. Characterization of proteins involved in disease progression in Alzheimer disease

   Author : Michael Axenhus; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alzheimer disease (AD) is a neurodegenerative disease and severe neuronal loss is already taking place at the time of diagnosis. AD affects nearly 50 million people worldwide and the incidence is expected to rise significantly in the coming decades, making the disease a high priority healthcare concern. READ MORE

6. 4. Resolving inflammation : analysis of mechanisms in relation to Alzheimer pathology and aging

   Author : Ceren Emre; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Alzheimer’s disease (AD) is the most common type of dementia, and its clinical symptoms are the reflections of pathological changes in the brain. The main pathological features of AD are intracellular aggregates of hyper-phosphorylated tau protein and extracellular deposits of amyloid β (Aβ) peptide in amyloid plaques. READ MORE

7. 5. Beta-amyloid processing and alpha7 neuronal nicotinic acetylcholine receptors in Alzheimer's disease-related mouse models : interactive mechanisms with focus on new drug targets

   Author : Monika M Hedberg; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Accumulation of beta-amyloid (Abeta), neuronal loss and changes in neurotransmitter systems, in particular the cholinergic system, are consistent features of Alzheimer s disease (AD). Abeta is thought to play a critical role in the pathogenesis of AD and it has therefore become a target of interest as regards a therapeutic approach. READ MORE