Search for dissertations about: "mice"

Showing result 1 - 5 of 2498 swedish dissertations containing the word mice.

  1. 1. Neurodevelopmental Consequences of Exposure to Paracetamol (Acetaminophen) and Related Drugs : Experimental studies in mice

    Author : Gaëtan Philippot; Robert Fredriksson; Vesna Jevtovic-Todorovic; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; paracetamol acetaminophen ; developmental neurotoxicology; delta9-tetrahydrocannabinol THC ; ibuprofen; endocannabinoid system; neonatal mice; brain growth spurt; behavior; Biology with specialization in Environmental Toxicology; Biologi med inriktning mot miljötoxikologi;

    Abstract : Paracetamol (acetaminophen) is the analgesic pharmaceutical most commonly used during pregnancy and early life. While therapeutic doses of paracetamol are considered harmless during these periods, recent findings in both humans and rodents suggest a link between developmental exposure to paracetamol and behavioral consequences later in life. READ MORE

  2. 2. Vascular Wall Responses to Bypass Grafting - Studies in Mice

    Author : Klas Österberg; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : Intimal hyperplasia; graft stenosis; smooth muscle cells; mice; cellular recruitment;

    Abstract : Abstract Vein grafts are frequently used in bypass surgery for treatment of coronary artery disease and lower limb ischemia. Unfortunately the long-term patency is impaired by vein graft stenoses due to intimal hyperplasia (IH). It is assumed that exaggerated intimal thickening is initiated by vessel wall injuries or local flow disturbances. READ MORE

  3. 3. THE ANGIOGENIC RESPONSE IN HYPOXIC HEART. Experimental studies in mice

    Author : Fei Tian; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : hypoxia; angiogenesis; mice; endoglin; SUMO; PDI;

    Abstract : Coronary artery disease is the leading cause of death in the western world today. Although induction of angiogenesis would appear to be an ideal therapeutic strategy, clinical trials of proangiogenic factors have proved disappointing. READ MORE

  4. 4. The expression and function of CD25 B cells in man and in mice

    Author : Amu Sylvie; Göteborgs universitet; Göteborgs universitet; Gothenburg University; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; B cell; CD25; rheumatoid arthritis; systemic lupus erythematosus; mice;

    Abstract : B cells play an important role both in the physiology and pathology of immune responses by production of antibodies, cytokines and by presentation of antigens. It has been shown that human CD25 expressing B cells display a mature phenotype, perform better as antigen presenting cells but secrete less immunoglobulins. READ MORE

  5. 5. T-cell Differentiation and Immunological Homeostasis in Lymphopenic and Kappa Light Chain Deficient Mice

    Author : Frida Ekholm Pettersson; Fredrik Ivars; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biochemistry; T cells; differentiation; homeostasis; cytokines; mice; SCID; κ-deficient; Biokemi; Biochemistry; Biokemi; immunologi; Immunology;

    Abstract : T lymphocytes are primarily involved in adaptive, cell-mediated, immune reactions. In this thesis T cells were studied regarding central and peripheral differentiation and homeostatic mechanisms for maintanance of the immune repertoire.The influence by mature T cells on thymic development was studied in C. READ MORE