Search for dissertations about: "microRNA biomarkers"

Showing result 1 - 5 of 29 swedish dissertations containing the words microRNA biomarkers.

  2. 1. Bioinformatics tools for discovery and evaluation of biomarkers : Applications in clinical assessment of cancer

    Author : Benjamin Ulfenborg; Björn Olsson; Karin Klinga-Levan; Erik Larsson Lekholm; Högskolan i Skövde; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Algorithms; biomarkers; machine learning; classification; cancer; microRNA database; microRNA discovery; partial least squares; Medical sciences; Medicin; Bioinformatik; Bioinformatics; Biomedicin;

    Abstract : Cancer is a disease characterized by abnormal proliferation of cells in the body and ranks as the second leading cause of death worldwide. In order to improve cancer patient care, a major focus of cancer research is to discover biomarkers. READ MORE

  4. 2. MicroRNA expression profiles in prostate cancer bone metastases : functional effects of microRNA-23c, -375, and -4328

    Author : Helena Järemo; Pernilla Wikström; Maria Brattsand; Anders Bergh; Elin Thysell; Guido Jenster; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer bone metastases; microRNA; metastatic subtypes; extracellular vesicles; Pathology; patologi;

    Abstract : Non-coding microRNAs (miRNAs) function as post-transcriptional regulators of gene expression by interacting with messenger RNA. Dysregulation of miRNAs has many possible consequences, including tumor-suppressive or -promoting ones, and restoring or preventing the effects of miRNA alteration has therapeutic potential. READ MORE

  5. 3. New Biomarkers for Neuromuscular Function and Myasthenia Gravis

    Author : Carl Johan Molin; Anna Rostedt Punga; Johan Widenfalk; Nils Hailer; Jan Verschuuren; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Biomarkers; myasthenia gravis; neuromuscular function; neurophysiology;

    Abstract : Myasthenia gravis (MG) is an autoimmune disorder, which is caused by autoantibodies against the acetylcholine receptor (AChR). The cardinal symptom is muscle fatigue, which can range from slight weakness of the extraocular muscles (causing droopy eyelids or double vision), to paralysis of the respiratory muscles. READ MORE

  6. 4. Oncolytic Adenovirus Therapy of Neuroendocrine Tumors

    Author : Justyna Leja; Magnus Essand; Valeria Giandomenico; Akseli Hemminki; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; adenovirus; virotherapy; oncolytic virus; neuroendocrine tumors; chromogranin A; somatostatin receptors; microRNA; novel biomarkers; Molecular biology; Molekylärbiologi; Oncology; Onkologi; Virology; Virologi; Tumour biology; Tumörbiologi; Medical Science; Medicinsk vetenskap; Oncology; Onkologi; Medical Virology; Medicinsk virologi; Molekylär cellbiologi; Molecular Cellbiology;

    Abstract : Neuroendocrine tumors (NETs), originally described as carcinoids, represent a rare and heterogeneous group of neoplasms associated with intensive secretion of hormones, bioactive peptides and amines. Most of the patients are diagnosed at a late stage of disease, often with liver metastases. READ MORE

  7. 5. Ultrasound and molecular biomarkers for prediction of preterm delivery in different risk groups of singleton pregnancies

    Author : Tove Wikström; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cervical length measurement; preterm birth; ; second trimester; screening; cost-effectiveness analyzes; progesterone; human microbiome; ; transcriptome; gene expression profiles; microRNA;

    Abstract : Ultrasound and molecular biomarkers for prediction of preterm delivery in women with a singleton pregnancy Tove Wikström Department of Obstetrics and Gynecology, Institute of Clinical Sciences Sahlgrenska Academy, University of Gothenburg Gothenburg, Sweden Background: Preterm delivery (PTD) is the leading cause of death in children under five years of age. Spontaneous PTD (sPTD) might be partly preventable by treating asymptomatic women having a short cervical length (CL) with vaginal progesterone. READ MORE