Search for dissertations about: "microbicides"

Found 4 swedish dissertations containing the word microbicides.

  2. 1. Towards a New Generation of Anti-HIV Drugs : Interaction Kinetic Analysis of Enzyme Inhibitors Using SPR-biosensors

    Author : Malin Elinder; U. Helena Danielson; Maurizio Botta; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; drug discovery; fragment; screening; reverse transcriptase; microbicides; interaction analysis; NNRTIs; Biochemistry; Biokemi; Biokemi; Biochemistry;

    Abstract : As of today, there are 25 drugs approved for the treatment of HIV and AIDS. Nevertheless, HIV continues to infect and kill millions of people every year. Despite intensive research efforts, both a vaccine and a cure remain elusive and the long term efficacy of existing drugs is limited by the development of resistant HIV strains. READ MORE

  4. 2. Prevalance and prevention of sexually transmitted viral infections in the Bolivian Amazonas

    Author : Marianela Patzi Churqui; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sexually transmitted infections; indigenous women; Bolivian Amazonas; medical plants; microbicides; cytokines; HSV-2; HPV; HBV;

    Abstract : This thesis investigates the prevalence of sexually transmitted viral infections in women living in the Amazonas region of Bolivia and explores whether Bolivian medical plants can affect the immune system and prevent or treat infections with Herpes simplex virus type 2 (HSV-2) and inflammation. My PhD project was financed by the Swedish International Development Cooperation Agency (SIDA), and I did my work alternately in Bolivia and in Sweden. READ MORE

  5. 3. Epithelial barrier protection : implications for HIV susceptibility

    Author : Gabriella Edfeldt; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The majority of HIV infections today occur through sexual HIV transmission. The female genital mucosa offers a barrier against incoming pathogens. Although, studies show that the vaginal microbiome, co-current infections and local inflammation, the use of hormonal contraceptives and microbicides, can weaken this protective lining. READ MORE

  6. 4. Factors associated with HIV susceptibility in the female genital tract

    Author : Frideborg Bradley; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The majority of new HIV infections in women are transmitted through vaginal intercourse where the female genital tract (FGT) functions as the portal of viral entry. The aim of this thesis was to characterize mucosal factors within the FGT to better understand potential molecular mechanisms associated with altered HIV-susceptibility. READ MORE