Search for dissertations about: "microenvironment"

Showing result 1 - 5 of 341 swedish dissertations containing the word microenvironment.

  2. 1. Imaging the tumor microenvironment : the dynamics and modification of hypoxia

    Author : Anna Ljungkvist; Peggy L. Olive; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Radiology; tumor microenvironment; double hypoxic marker method; proliferation; hypoxia; hypoxic half-life; Radiologisk forskning; Radiological research; Radiologisk forskning; diagnostisk radiologi; Diagnostic Radiology;

    Abstract : The tumor vasculature is poor and heterogeneous which may result in inadequate oxygenation and changed energy status. In addition the balance between cell proliferation and the rate of cell death is disturbed, which results in tumor growth. READ MORE

  4. 2. Targeting the prostate tumor microenvironment and vasculature : the role of castration, tumor-associated macrophages and pigment epithelium-derived factor

    Author : Sofia Halin; Anders Bergh; Pernilla Wikström; Stina Rudolfsson; Carl-Henrik Heldin; Umeå universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Prostate cancer; angiogenesis; castration therapy; microenvironment; stroma; tumor-associated macrophages; pigment epithelium-derived factor; PEDF; vasculature; Pathology; Patologi; patologi; Pathology;

    Abstract : BACKGROUND: Prostate cancer is the most common cancer among Swedish men. For patients with metastatic prostate cancer the standard therapy is castration, a treatment that initially provides symptomatic relief but unfortunately is not curative. New therapeutic targets for advanced prostate cancer are therefore needed. READ MORE

  5. 3. Studies of the tumor microenvironment : Local and systemic effects exerted by the cross-talk between tumor and stroma cells in pancreatic cancer

    Author : Vegard Tjomsland; Marie Larsson; Arne Östman; Linköpings universitet; []
    Keywords : Pancreatic cancer; cancer associated fibroblasts; dendritic cells; IL-1alpha; tumor microenvironment; inflammation; bukspottkörtelcancer; Bukspyttkjertel kreft; MEDICINE; MEDICIN;

    Abstract : Pancreatic cancer is one of the most lethal cancers and despite all research efforts the last 50 years, there are still no effective therapy for this terrible disease. Until quite recently most research in the field of pancreatic duct adenocarcinoma (PDAC) was focused on the tumor cells and mechanisms essential for their proliferation and survival. READ MORE

  6. 4. Dissecting the Microenvironment of Urothelial Bladder Cancer : Therapy, Modelling and Biomarkers

    Author : Iliana Kyriaki Kerzeli; Sara Mangsbo; Tania de Gruijl; Uppsala universitet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; NATURVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; MEDICIN OCH HÄLSOVETENSKAP; NATURAL SCIENCES; MEDICAL AND HEALTH SCIENCES; MEDICAL AND HEALTH SCIENCES; Immuno-oncology; Tumor immunology; MALT1 inhibition; Urothelial bladder cancer; Tumor microenvironment; Immunologi; Immunology; Oncology; Onkologi; Urologi; Urology;

    Abstract : The complexity of the tumor microenvironment (TME) impacts therapy responses and the survival of cancer patients. The scope of this thesis is to study the effects of immune modulation on tumor-infiltrating leukocytes, and to explore the TME of urothelial cancer to provide the research society with new knowledge and potential therapeutic targets. READ MORE

  7. 5. Growth factor signaling in the breast tumor microenvironment

    Author : Matteo Bocci; Avdelningen för translationell cancerforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; Tumor microenvironment; Angiogenesis; Cancer-associated fibroblasts; PDGF-C; ALK1;

    Abstract : Cancer represents a collection of malignancies characterized by an aberrant expansion of cells. This unrestrained growth is the result of the acquisition of several pro-survival features and the evasion of cellular fail-safe mechanisms, collectively known as the hallmarks of cancer. READ MORE