Search for dissertations about: "microenvironment"

Showing result 21 - 25 of 376 swedish dissertations containing the word microenvironment.

  2. 21. Pancreatic cancer – Influence of Tumour Microenvironment

    Author : Chinmay Gundewar; Lund Kirurgi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Pancreatic cancer (PC) is the fourth leading cause of cancer-related deaths, with a 5-year survival less than 6%. It does not show any symptoms in its early stages, hence most (>85%) of the patients are diagnosed at late stage. READ MORE

  4. 22. Dissection of the tonsillar cancer immune microenvironment : Perspectives of the myeloid APC – T-cell axis

    Author : David Gomez Jimenez; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dendritic cell; Macrophage; CD8 T-cell; Human papillomavirus HPV ; Tonsillar cancer; Tumor microenvironment; Immuno-oncology; Single-cell RNA sequencing; Spatial proteomics; Flow Cytometry;

    Abstract : Tonsillar cancer (TC) is a subset of head and neck cancer (HNC). TC incidence is sharply rising due to an increased prevalence of human papillomavirus (HPV) infection in the western world. Currently HPV status is considered during clinical staging due to its positive association to patient prognosis. READ MORE

  5. 23. Molecular Investigations of high-risk Mantle Cell Lymphoma : Genetic factors and the impact of the microenvironment

    Author : Joana de Matos Rodrigues; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mantle cell lymphoma MCL ; CPT1A; TP53; c-Myc; Immune microenvironment; Macrophages;

    Abstract : Mantle cell lymphoma (MCL) is an aggressive disease, with variable clinical course and heterogenous molecular characteristics. In this thesis, which is based upon six original papers, we aimed to understand MCL deregulations, both at intrinsic and extrinsic levels, to identify companion biomarkers that would allow patient stratification. READ MORE

  6. 24. The breast cancer microenvironment and cancer cell secretion - specific effects on cancer progression and subtypes of cancer cells

    Author : Emma Persson; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Breast cancer; cancer microenvironment; secretion; hypoxia;

    Abstract : Breast cancer is the cancer form responsible for the most cancer-related deaths among women worldwide, and novel targeted therapies are highly needed. The tumor microenvironment consists of several components, including different cell types, extracellular matrix, oxygen and nutrient gradients and soluble factors that plays a key role in cancer progression. READ MORE

  7. 25. Exploring immunotherapeutic targets in the tumor microenvironment

    Author : Anna-Maria Georgoudaki; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The immune system has developed along with the evolution of increasingly complex cellular organisms to sustain homeostasis and protect from threats. Cancer, a detrimental side effect of increasing organismic complexity, typically sequesters the immune system and hijacks its functions for its own prosperity. READ MORE