Search for dissertations about: "microglial load"

Found 4 swedish dissertations containing the words microglial load.

  2. 1. Implications of cholesterol and cholesterol-lowering therapy in Alzheimer's disease

    Author : Daniel Famer; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Alzheimer s disease; dietary cholesterol; rosuvastatin; apolipoprotein E; alpha-secretase; beta-secretase; alpha- beta-secretase ratio; soluble APPalpha; gliosis; microglial load; interleukin-6; caspase-3; body weight gain; lifestyle-preventive strategy; 24 S -hydroxycholesterol; 27-hydroxycholesterol;

    Abstract : BACKGROUND: Alzheimer's disease (AD) is a severe neurodegenerative disease that mainly afflicts elderly persons, with a characteristic progressive decline of cognitive functions and dementia. It is believed that the majority of all AD patients are affected by the sporadic form, thus caused by the combined effects of several risk factors, such as elevated cholesterol levels in midlife and deficiencies in the lipoprotein transporters apolipoprotein E (ApoE). READ MORE

  4. 2. Short- and long-term consequences of sport-related concussion

    Author : Fredrik Vedung; Niklas Marklund; Gunnar Antoni; Elna-Marie Larsson; Jakob Johansson; Alexander Olsen; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Sport-related concussion; Soccer; Traumatic brain injury; tau; neuroinflammation; cerebral blood flow; Neurokirurgi; Neurosurgery;

    Abstract : Concussions are common in contact sports. Symptoms such as confusion and/or loss of consciousness following an impact to the head indicate that a sport-related concussion (SRC) has occurred. The symptoms normally resolve within 10-14 days following an SRC in adults although at least 10 % of athletes suffer from prolonged symptoms. READ MORE

  5. 3. Pathophysiological Mechanisms and Diagnostic Markers in Alzheimer’s Disease

    Author : Joakim Hertze; Klinisk minnesforskning; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer’s disease; mild cognitive impairment; white matter lesions; brain reserve; blood-brain barrier; angiogenesis; neuroinflammation; neurogranin; YKL-40; VEGF; IGF; ICAM-1; VCAM-1;

    Abstract : Alzheimer’s disease (AD), the most common cause of dementia, is a growing concern. As the life expectancy increases across the globe, the number of affected people is estimated to reach 100 million by 2050. READ MORE

  6. 4. Molecular dynamics in HIV-1 infection of the brain

    Author : Mariantonietta Di Stefano; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The focus of the present thesis was to investigate the molecular dynamics in HIV-l infection of the brain. HIV-l infects the brain early during the infection and causes neurological syndromes and neuropathological modifications. READ MORE