Search for dissertations about: "microsome"

Showing result 1 - 5 of 7 swedish dissertations containing the word microsome.

  2. 1. Drug Transport and Metabolism in Rat and Human Intestine

    Author : Sofia Berggren; Hans Lennernäs; Janet Hoogstraate; Patrick Augustijns; Uppsala universitet; []
    Keywords : Biopharmacy; Ussing chamber; microsome; single-pass perfusion; human; rat; intestine; permeability; efflux; P-glycoprotein; metabolism; cytochrome P450; ropivacaine; lidocaine; bupivacaine; Biofarmaci; PPX;

    Abstract : One of the aims of this thesis was to investigate the involvement of efflux proteins, such as the P-glycoprotein (Pgp), in the drug transport in different regions of the rat and the human intestine. The intestinal extrusion of intracellularly formed CYP3A4 metabolites, including whether this extrusion might be mediated by Pgp, was also studied. READ MORE

  4. 2. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process

    Author : Malin Nilsson Broberg; Mikael Hedeland; Ulf Bondesson; Curt Pettersson; Börje Tidstedt; Peter Van Eenoo; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Mass spectrometry; UHPLC-HRMS; Doping control; Metabolite profile; SARM; Selective Androgen Receptor Modulator; MVDA; Microsomes; Experimental design; Analytisk farmaceutisk kemi; Analytical Pharmaceutical Chemistry;

    Abstract : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. READ MORE

  5. 3. Chemical analysis of complex mixtures with regard to potentially genotoxic organic compounds

    Author : Tomas Alsberg; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : This thesis describes different methods for the extraction, fractionation, and analysis of particle adsorbed organic compounds. The utility of capillary gas chromatography mass spectrometry (GC-MS) for the analysis of polycyclic aromatic compounds (PAC) is demonstrated. READ MORE

  6. 4. Genotoxic hazards in the rubber industry : application of short-term tests in work environment analyses

    Author : Agneta Rannug; Stockholms universitet; []
    Keywords : ;

    Abstract : Excess mortality from a number of different types of cancer has been associated with work in the rubber industry. The aim of the present study - using short-term tests for mutagenicity - was to identify potentially hazardous additives and process fumes to which workers are exposed. READ MORE

  7. 5. Design and Synthesis of Novel HIV-1 Protease Inhibitors Comprising a Tertiary Alcohol in the Transition-State Mimic

    Author : Jenny Ekegren; Anders Hallberg; Daniel Rich; Uppsala universitet; []
    Keywords : Chemistry; HIV AIDS; HIV-1 protease inhibitor; transition-state mimic; tertiary alcohol; palladium; cross-coupling; aminocarbonylation; microwave; molybdenum hexacarbonyl; Kemi;

    Abstract : HIV-1 protease inhibitors are important in the most frequently used regimen for the treatment of HIV/AIDS, the highly active antiretroviral therapy (HAART). For patients with access to this treatment, an HIV infection is no longer lethal, but rather a manageable, chronic infection. READ MORE