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Showing result 1 - 5 of 55 swedish dissertations matching the above criteria.
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1. Metabolite Profiling of Drugs using Mass Spectrometry : Identification of analytical targets for doping control and improvements of the metabolite search process
Abstract : Doping is defined as the use of prohibited substances or methods by the World Anti-Doping Agency and the aim with doping control analysis is to detect the use of these illicit substances or methods. Substances that are prohibited in human or equine sports have either a positive or negative impact on the performance. READ MORE
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2. Fatty acid hydroxylation in rat kidney and liver microsomes
Abstract : .... READ MORE
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3. Cytochromes P-450 in biosynthesis of bile acids and metabolism of vitamin D3 : studies on cytochrome P-450 isozymes in rat liver microsomes
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4. Proteomics-informed analysis of drug disposition in the human liver and small intestine
Abstract : Orally administered drugs are absorbed in the intestine and generally metabolized in the liver. Therefore, understanding factors determining drug distribution and elimination in these tissues is important. READ MORE
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5. Drug transport and metabolism in in vitro models of the human intestine : By Shamsi D. Raeissi
Abstract : The objective of this thesis was to study the mechanisms of drug transport and metabolism in two different in vitro models of the human intestine: monolayers of human intestinal epithelial cell lines and intestinal microsomes. The first part of the thesis shows that Caco-2 cell monolayers are a good model for mechanistic studies of drug transport. READ MORE