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Showing result 1 - 5 of 31 swedish dissertations matching the above criteria.

2. 1. Microwave-Assisted Synthesis of C2-Symmetric HIV-1 Protease Inhibitors : Development and Applications of In Situ Carbonylations and other Palladium(0)-Catalyzed Reactions

   Author : Johan Wannberg; Anders Hallberg; David C. Rees; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; HIV; protease inhibitors; palladium; carbonylations; molybdenum hexacarbonyl; dihydropyrimidone; DHPM; microwave; cross-coupling; diazylhydrazines; carbon monoxide; synthesis; C2-symmetric; HIV-1 protease inhibitors; aminocarbonylation; fluorous; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi;

   Abstract : The HIV protease is an essential enzyme for HIV replication and constitutes an important target in the treatment of HIV/AIDS. Efficient combination therapies using inhibitors of the reverse transcriptase and protease enzymes have led many to reevaluate HIV infections from a terminal condition to a chronic-but-manageable disease in the developed world. READ MORE

4. 2. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry

   Author : Kristina M. Orrling; Mats Larhed; Fredrik Almqvist; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; microwave-assisted chemistry; malaria; aspartic protease; plasmepsin; PfPM4; PmPM4; PoPM4; PvPM4; inhibitor; unsaturated lactone; unsaturated lactam; unsaturated amide; lactam; Bestmann s ylide; ionic liquid; polymerase chain reaction; thermophilic enzyme; Pharmaceutical chemistry; Läkemedelskemi; Organic synthesis; Organisk syntes; Biochemistry; Biokemi; Biochemistry; biokemi;

   Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE

5. 3. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria

   Author : Hans Emtenäs; Ulf Nilsson; Umeå universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; β-lactam; 2-pyridinone; 2-pyridone; Meldrum’s acid; Δ2-thiazoline; solid-phase synthesis; microwave assisted synthesis; antibacterial; pili; pilicide; Organisk kemi; Organic chemistry; Organisk kemi; organisk kemi; Organic Chemistry;

   Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE

6. 4. Microwave-assisted transformations of lignin for value-added material applications

   Author : Jenevieve G. Yao; Minna Hakkarainen; Karin Odelius; Monika Österberg; KTH; []
   Keywords : lignin; microwave-assisted processes; organosolv fractionation; esterification; fused filament fabrication; digital light processing; lignin; mikrovågsassisterade strategier; organosolv-fraktionering; förestring; additiv tillverkning; Fiber- och polymervetenskap; Fibre and Polymer Science;

   Abstract : The chemical diversity and structural complexity of lignin, an abundant biopolymer found in vascular plants, present a multitude of opportunities for the modification and fine-tuning of its properties to suit downstream demands. In this thesis, microwave-assisted strategies were explored as efficient and environment-friendly pathways for lignin valorization towards value-added material applications. READ MORE

7. 5. Design, Synthesis and Evaluation of Catalytic Chalcogenide Antioxidants

   Author : David Shanks; Lars Engman; John C Walton; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; antioxidant; tellurium; selenium; computational design; homolytic substitution; radical cyclisation; microwave-assisted synthesis; antioxidant regeneration; Organisk kemi; Organic chemistry; Organisk kemi;

   Abstract : This thesis describes the design, synthesis and evaluation of novel chalcogenide antioxidants.A computational model for the prediction of antioxidant properties of chalcogen-containing antioxidants has been developed. READ MORE