Search for dissertations about: "microwave organic synthesis"
Showing result 1 - 5 of 40 swedish dissertations containing the words microwave organic synthesis.
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1. New Methodologies in Organic Chemistry: Applications to the Synthesis of α-Amino Acids and Natural Products
Abstract : This thesis deals with the development and application of new synthetic methodology in organic chemistry. The first part describes the development of a new protocol for the synthesis of 3-pyrrolines by means of a microwave-assisted ring-expansion reaction of 2-vinylaziridines. READ MORE
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2. Synthesis and biological evaluation of Bicyclic β-Lactams and 2-Pyridinones : Pilicides Targeting Pilus Biogenesis in Pathogenic Bacteria
Abstract : New methods have been developed for the synthesis of bicyclic β-lactams and 2-pyridinones by combining acyl Meldrum’s acids and Δ2-thiazolines. The 2-pyridinones were synthesised both in solution using conventional heating or microwave assisted heating as well as by solid supported chemistry. READ MORE
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3. Palladium(II)-Catalyzed Addition Reactions : Synthesis of Aryl Amidines and Aryl Ketones
Abstract : Palladium-catalyzed reactions have become one of the most important tools in modern organic chemistry due to its ability to catalyze the formation of new carbon-carbon bonds.The aim of the work presented in this thesis was to develop new palladium(II)-catalyzed addition reactions. READ MORE
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4. On the Versatility of Microwave-Assisted Chemistry : Exemplified by Applications in Medicinal Chemistry, Heterocyclic Chemistry and Biochemistry
Abstract : Today, the demand for speed in drug discovery is constantly increasing, particularly in the iterative processes of hit validation and expansion and lead optimization. Irradiation with microwaves (MWs) has been applied in the area of organic synthesis to accelerate chemical reactions and to facilitate the generation of new chemical entities since 1986. READ MORE
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5. Imaging of Enzymes in the Steroid Biosynthetic Pathway : Synthesis of 18F-Labelled Tracers
Abstract : This thesis deals with the synthesis and development of 18F-labelled alkyl etomidate and vorozole analogues, and their use as positron emission tomography (PET) tracers for the imaging of the steroid enzymes 11β-hydroxylase and aromatase. Two synthetic 18F-labelling approaches to the etomidate and vorozole analogues were developed, and the analogues were evaluated in some biological assays. READ MORE