Search for dissertations about: "microwell"

Showing result 6 - 10 of 15 swedish dissertations containing the word microwell.

  2. 6. Digital Electrical DNA Sensing

    Author : Maoxiang Guo; Wouter van der Wijngaart; Fredrik Westerlund; KTH; []
    Keywords : DNA detection; thiol-ene-epoxy; rolling circle amplification; digital measurement; DNA stretching; microwell-array; gold nanowires; electrical measurement; specificity; limit of detection; liquid storage; disease diagnosis; lab-on-a-chip; point-of-care.;

    Abstract : Molecule detection is a workhorse in life sciences and medicine, for example in cancer diagnosis and virus and bacterial detection. DNA analysis can provide vital information about the state of a host organism and its medical and health condition. READ MORE

  4. 7. Towards personalized immunotherapy : development of in vitro models for imaging natural killer cell behavior in the tumor microenvironment

    Author : Valentina Carannante; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Tremendous advances in the tumor immunology field have transformed immunotherapy from a promising approach to a standard clinical practice. However, a subset of cancer patients is non-responsive to immunotherapy. More research is therefore needed to understand the mechanisms underlying tumor resistance to immunotherapeutic treatments. READ MORE

  5. 8. Single cell studies of human T cell function with applications for HIV-1

    Author : Johanna Tauriainen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : T cells are one of the body’s main defenses against viruses and cancers and are therefore considered to play a major role in immunotherapies after stem cell transplantation and in HIV-1 vaccine and cure strategies. However, malignancies and chronic viral infections, such as HIV-1, eventually cause the T cells to become dysfunctional, resulting in a loss of control. READ MORE

  6. 9. Microscopy-based single-cell in vitro assays for NK cell function in 2-D and 3-D

    Author : Per Erik Olofsson; Björn Önfelt; Khakoo Salim; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biological Physics; Biologisk fysik;

    Abstract : Natural killer (NK) cells are effector cells of the innate immune system that are responsible for mediating cellular cytotoxicity against virally infected or neoplastically transformed cells. NK cell subsets are defined by their expression of certain cell-surface markers, and are usually related to activation and developmental status. READ MORE

  7. 10. Development of Microchip-based Assays to Study Immune Cell Interactions at the Single Cell Level

    Author : Karolin Guldevall; Björn Önfelt; Hjalmar Brismar; Antonio Barragan; KTH; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Bioengineering; Bioteknik;

    Abstract : Immune cell populations are constantly divided into smaller and smaller subsets defined by newly emerging cellular markers. However, there is a growing awareness of the functional heterogeneities in between cells even within small populations, in addition to the heterogeneity over time. READ MORE