Search for dissertations about: "midbrain dopaminergic neurons"

Showing result 1 - 5 of 64 swedish dissertations containing the words midbrain dopaminergic neurons.

2. 1. Generation of Dopaminergic Neurons from Human Embryonic Stem Cells

   Author : Tandis Vazin; Joakim Lundeberg; Ernest Arenas; KTH; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Human; dopaminergic; embryonic stem cells; differentiation; stromal cells; PA6 cells; dopamine; neurons; Neuroscience; Neurovetenskap; Neurobiology; Neurobiologi; Molecular neurobiology; Molekylär neurobiologi;

   Abstract : Since the first successful derivation of human embryonic stem cells (hESC), rapid progress has been attained in the development of strategies in differentiation of these cells into various neural lineages, with the fundamental objective of using these cells for replacement and repair of damaged neuronal circuits in the central nervous system (CNS). Of particular interest are midbrain dopaminergic (mDA) neurons, which play a central role in regulation of voluntary movement. READ MORE

4. 2. Directing and Dissecting the Fate of Dopaminergic Neurons - Multiple Avenues towards Cell Replacement Therapy in Parkinson's Disease

   Author : Sara Nolbrant; Utvecklings- och regenerativ neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Dopaminergic neurons; Cell replacement therapy; Parkinson s disease; Human pluripotent stem cells; Cell differentiation; Direct neuronal reprogramming; glial progenitors; midbrain development;

   Abstract : .... READ MORE

5. 3. Direct Conversion of Human Fibroblasts to Induced Neurons

   Author : Ulrich Pfisterer; Utvecklings- och regenerativ neurobiologi; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cellular Reprogramming; Direct Conversion; Human Induced Neurons; Dopaminergic; Cell Replacement Therapy; Lentiviral Vectors;

   Abstract : During direct cellular reprogramming, forced expression of key transcription factors (TFs) directly converts one terminally differentiated cell type into that of another fate, exemplified in this theses by the conversion of fibroblasts into functional induced neurons (iNs). Direct conversion of mouse fibroblasts to functional neurons was established in 2010, and the starting point of my doctoral thesis was the aim to transfer iN-technology to human cells and to explore the potential of this technique in regards to generate subtype-specific neurons as well as to use these cells for transplantation studies. READ MORE

6. 4. Wnt/beta-catenin signaling in midbrain dopaminergic neurons

   Author : Nina Rawal; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Dopamine; neuron; development; beta-catenin; Writ; Parkin; Parkinson s disease;

   Abstract : Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. READ MORE

7. 5. Towards cell replacement therapy in Parkinson’s disease. Proteoglycans and Nogo-A as modulators of axonal growth in midbrain dopaminergic neurons

   Author : Zuzanna Kurowska; Neural plasticitet och reparation; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; LUHMES cells; substantia nigra pars compacta; microarray; heparan sulphate 3-O-sulfotransferase; neurocan; midbrain dopaminergic neurons; grafting; embryonic stem cells; proteoglycans; glycosaminoglycans; Nogo-A; cell replacement therapy; Parkinson’s disease;

   Abstract : Parkinson’s disease (PD) is currently the second most common neurodegenerative disorder (after Alzheimer’s disease). PD is diagnosed on its motor symptoms, which include akinesia, bradykinesia, rigidity, postural imbalance and resting tremor. It is well established that the motor symptoms develop due to lack of dopamine in the striatum. READ MORE