Search for dissertations about: "midbrain"
Showing result 1 - 5 of 115 swedish dissertations containing the word midbrain.
-
1. United in Diversity : A Physiological and Molecular Characterization of Subpopulations in the Basal Ganglia Circuitry
Abstract : The Basal Ganglia consist of a number of different nuclei that form a diverse circuitry of GABAergic, dopaminergic and glutamatergic neurons. This complex network is further organized in subcircuits that govern limbic and motor functions in humans and other vertebrates. READ MORE
-
2. Mechanisms controlling midbrain dopaminergic neuron development
Abstract : The degeneration of midbrain dopaminergic (mDA) neurons accounts for some of the main motor symptoms of Parkinson’s disease (PD). Efforts during the last decades have focused on understanding how mDA neurons are generated and maintained with the hope of developing novel stem cell-based replacement therapies. READ MORE
-
3. Wnts in development : focus on midbrain
Abstract : Studies in the field of embryonic development reveal the temporal and spatial requirement of specific genes/proteins in the formation of a given tissue. The specific knowledge of which genes/proteins regulate development of the ventral midbrain (VM) provides a guideline for the in vitro differentiation of specific cell types therein, such as dopaminergic (DA) neurons. READ MORE
-
4. Wnt/beta-catenin signaling in midbrain dopaminergic neurons
Abstract : Parkinson's disease (PD) is caused by a progressive degeneration of the dopaminergic (DA) neurons of the substantia nigra. However, the mechanisms underlying the degeneration remain elusive and there is no cure for P1) at present. READ MORE
-
5. The Wnt pathway in ventral midbrain dopaminergic differentiation
Abstract : Parkinson’s disease (PD) is a debilitating neurodegenerative disease in which dopaminergic (DA) neurons in the substantia nigra are lost. Current treatments such as administration of levodopa (L-DOPA) are initially effective but the disease eventually progresses, highlighting the need for a treatment that restores and maintains the otherwise lost functions. READ MORE