Search for dissertations about: "mikrofysiologiska system"

Found 3 swedish dissertations containing the words mikrofysiologiska system.

  2. 1. Organic Electronics and Microphysiological Systems to Interface, Monitor, and Model Biology

    Author : Sebastian Buchmann; Anna Herland; Erica Zeglio; Agneta Richter-Dahlfors; Maria Asplund; KTH; Karolinska Institutet; Karolinska Institutet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; organic bioelectronics; organic electrochemical transistors; conjugated polymers; microphysiological systems; in vitro cell models; Organisk bioelektronik; organiska elektrokemiska transistorer; Konjugerade polymerer; Mikrofysiologiska system; in vitro-modeller; Medicinsk teknologi; Medical Technology;

    Abstract : Biological processes in the human body are regulated through complex and precise arrangements of cell structures and their interactions. In vivo models serve as the most accurate choice for biological studies to understand these processes. However, they are costly, time-consuming, and raise ethical issues. READ MORE

  4. 2. Recreating the microenvironment of the neurovascular unit

    Author : Isabelle Matthiesen; Anna Herland; Thomas E. Winkler; Stéphanie Descroix; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; microphysiological systems; neurovascular unit; induced pluripotent stem cells; extracellular matrix; hydrogels; in vitro models; mikrofysiologiska system; neurovaskulära enheten; inducerade pluripotenta stamceller; extracellulära matrisen; hydrogeler; in vitro modeller; Bioteknologi; Biotechnology;

    Abstract : The neurovascular unit (NVU) comprises the blood-brain-barrier (BBB) and its surrounding astrocytes, pericytes and neurons that are embedded in the extracellular matrix (ECM). As the main function of the BBB is to protect the brain from inlet of pathogens and toxins, the specialized endothelial cells that keep the barrier tight will also hinder the passage of pharmaceuticals. READ MORE

  5. 3. Human iPSC-based models of theCNS: attaining cellular biofidelitythrough conventional and advancedculture systems

    Author : Dimitrios Voulgaris; Anna Herland; Susanna Narkhilakhi; KTH; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; neural stem cells; astrocytes; iPSC; hiAstrocytes; microphysiological systems; BBB; Bioteknologi; Biotechnology;

    Abstract : Brain development is a highly orchestrated process that entails changes in microenvironmental cues and growth factor gradients, which set the tempo for proper development of the rudimentary structures of the brain and the generation of neurons,astrocytes, and oligodendrocytes. Another intricate feature of the brain is the bloodbrain barrier (BBB). READ MORE