Search for dissertations about: "minigene"

Showing result 1 - 5 of 6 swedish dissertations containing the word minigene.

  2. 1. Functional genetics of the interleukin-4 receptors in allergic asthma

    Author : Ann-Marie Bergin; Göteborgs universitet; []
    Keywords : Asthma; association study; candidate genes; IL4R; CIITA; alternative splicing; minigene;

    Abstract : Asthma is a complex disorder, with both genetic and environmental factors contributing to disease development. Our aim was to analyse possible associations between genetic variations of immunologically important genes and the susceptibility to and severity of allergic asthma in adults. READ MORE

  4. 2. Functional studies of E. coli ribosomes and characterization of mini open reading frames

    Author : Vildan Dincbas; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Cell and molecular biology; Cell- och molekylärbiologi; Cell and molecular biology; Cell- och molekylärbiologi; molekylärbiologi; Molecular Biology;

    Abstract : In this thesis, problems concerning the elongation, termination and recycling steps of prokaryotic translation have been addressed.An explanation is given for growth inhibition due to minigene expression.Minigene transcripts containing very short open reading frames inhibit proteinsynthesis in E. READ MORE

  5. 3. Epithelial stem cells in Hutchinson-Gilford progeria syndrome

    Author : Tomás McKenna; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Hutchinson-Gilford progeria syndrome (HGPS) and restrictive dermopathy (RD) are two rare genetic disorders that affect children. Complications from cardiovascular disease, including atherosclerosis, are the most common cause of death in HGPS, which occurs at around 13 years of age. READ MORE

  6. 4. Type IV collagen : regulation of COL4A1 and COL4A2 genes and gene therapy of Alport syndrome

    Author : Pirkko Kortteinen; Karolinska Institutet; Karolinska Institutet; []
    Keywords : adenovirus; Alport syndrome; basement membrane; bidirectional promoter; collagen; gene regulation; gene therapy; promoter analysis; kidney gene transfer; organ perfusion; type IV collagen;

    Abstract : Type IV collagen is an important structural protein in basement membranes, which am thin sheet-like structures located between organized tissues and the connective tissue. Type IV collagen is composed of six genetically different [alpha] chains. READ MORE

  7. 5. Functional analysis of genetic variants in putative low penetrate breast cancer genes

    Author : Haixin Lei; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Breast cancer; low penetrance gene; CDH1; ILC; IDC; mutation; SNP; BA CHI; ATM; EST1; cryptic splice site; SR proteins; dinucleotide repeats; splicing silencer.;

    Abstract : Paper I & II: CDH1 germline mutations predispose individuals to diffuse gastric cancer, but its role in breast cancer is less clear. Somatic CDH1 mutations were reported to be frequent in lobular tumours (ILC), but they have not been found in ductal carcinomas (IDC). READ MORE