Search for dissertations about: "minimal residual disease"

Showing result 21 - 25 of 38 swedish dissertations containing the words minimal residual disease.

2. 21. Gene Expression Studies of Hematologic Malignacies

   Author : Anna Andersson; Avdelningen för klinisk genetik; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; extracellular fluids; Haematology; cancer; onkologi; Cytologi; oncology; Cytology; acute myeloid leukemia; acute lymphoblastic leukemia; normal hematopoietic cells; cDNA microarray; gene expression profiling; hematopoiesis; pediatric leukemia; fusion gene; Pediatrics; Pediatri; Clinical genetics; Klinisk genetik; cancerology; Hematologi; extracellulära vätskor;

   Abstract : The general aim of this thesis was to characterize hematologic malignancies using gene expression profiling in order to obtain an improved classification and to study deregulated transcriptional networks in leukemia. In the first study (Article I), the gene expression profiles of hematologic cell lines were analyzed to investigate whether such cell lines maintain expression profiles that are characteristic of their primary genetic changes. READ MORE

4. 22. Radioimmunotherapy of experimental ovarian cancer with Astatine-211. An in vivo model for consolidation treatment in women

   Author : Håkan Andersson; Göteborgs universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Astatine-211; consolidating treatment; in vitro effects; monoclonal antaibodies; Mov18; ovarian cancer; radioimmunotherapy;

   Abstract : About 850 new cases of ovarian cancer are diagnosed in Sweden every year. In 75 % of the patients the tumour has spread outside the ovaries. The standard treatment is surgery followed by six courses of combination chemotherapy. In spite of a very high frequency of clinical complete responses the 5-year survival is not satisfactory. READ MORE

5. 23. Umbilical cord blood transplantation : clinical outcome, chimerism development, and in vitro expansion of T-cells for clinical use

   Author : Sofia Berglund; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Umbilical cord blood (UCB) is an alternative graft source in allogeneic hematopoietic stem cell transplantation (HSCT). The unique advantages with UCB as a stem cell source are found in the permissibility for human leukocyte antigen (HLA)-mismatch, rapid availability, and comparatively risk-free graft collection. READ MORE

6. 24. Stem cell transplantation in multiple myeloma : clinical aspects and experimental gene transfer studies

   Author : Bo Björkstrand; Karolinska Institutet; Karolinska Institutet; []
   Keywords : multiple myeloma; bone marrow transplantation; allogeneic; autologous; prognostic factors; hemato-poietic stem eells; gene therapy; gene transfer; retrovirus; basic fibroblast growth factor;

   Abstract : Multiple myeloma (MM) is a hematological malignant disease considered essentially incurable despite its sensitivity to cytotoxic chemotherapeutic drugs and radiation. High-dose chemo/radiotherapy with allogeneic- or autologous hematopoietic stem cell transplantation (tx) can induce a disease-free state and may prolong survival and offer an improved quality of life to MM patients. READ MORE

7. 25. DNA methylation as a prognostic marker i acute lymphoblastic leukemia

   Author : Magnus Borssén; Sofie Degerman; Kim Vettenranta; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; DNA methylation; acute lymphoblastic leukemia; T-ALL; Relapse; Telomere length; patologi; Pathology; Pediatrics; pediatrik;

   Abstract : Acute lymphoblastic leukemia (ALL) is the most common childhood malignancy. Most ALL cases originate from immature B-cells (BCP-ALL) and are characterized by reoccurring structural genetic aberrations. These aberrations hold information of the pathogenesis of ALL and are used for risk stratification in treatment. READ MORE