Search for dissertations about: "mir-375"
Showing result 1 - 5 of 9 swedish dissertations containing the word mir-375.
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1. Effects of Ca2+, microRNAs, and rosuvastatin on insulin-secreting beta cell function
Abstract : Type 2 diabetes (T2D) is a condition of high blood glucose levels due to insulin resistance and defective insulin secretion. Impaired insulin secretion plays a major role in the pathophysiology of T2D, it is mainly attributed to beta cell function i.e. failure to secrete insulin or reduced beta cell mass. READ MORE
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2. Non-coding RNAs in beta cell insulin secretion - emerging players in Type 2 Diabetes pathogenesis
Abstract : Type 2 diabetes (T2D) is a complex polygenic disease influenced by both environmental and genetic factors resulting in impaired insulin release from pancreatic beta cells and insulin resistance in target tissues. The incidence of T2D is escalating and it is projected that over 640 million people will be affected by 2040. READ MORE
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3. Connecting viral oncoproteins to microRNA, autophagy and metabolism in Merkel cell carcinoma
Abstract : Merkel cell carcinoma (MCC) is an aggressive type of skin cancer. Around 80% of MCCs harbor an integrated Merkel cell polyomavirus (MCPyV) genome with a mutation in the large T antigen (LT) gene, leading to expression of truncated LT. It is evident that the viral truncated LT and small T antigen (sT) play important roles in MCC tumorigenesis. READ MORE
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4. Dissecting the role of micro-RNAs in diabetes
Abstract : The role of miRNAs in pancreatic islets and β-cell function and in the development of diabetes in human and rodents have been investigated in this thesis. Dicer1 was specifically deleted in vivo in pancreatic β-cells under the RIP-promoter in mice. READ MORE
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5. MicroRNA expression and function in virus-associated human cancers
Abstract : microRNAs (miRNAs) are small non-coding RNAs that play important roles in gene regulation. It is now clear that miRNAs participate in tumor development and progression. READ MORE