Search for dissertations about: "mitochondrial disorders"
Showing result 11 - 15 of 62 swedish dissertations containing the words mitochondrial disorders.
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11. Life without mitochondrial DNA : studies of transgenic mice
Abstract : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. READ MORE
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12. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects
Abstract : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. READ MORE
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13. Mitochondrial dysfunction in ageing and degenerative disease
Abstract : The cytoplasm of eukaryotic cells contains a dynamic network of double-membraned organelles, called mitochondria, which perform the process of oxidative phosphorylation (OXPHOS) that provides cellular energy in the form of ATP. The respiratory chain creates an electrochemical gradient across the inner mitochondrial membrane, which drives ATP synthesis by the ATP synthase. READ MORE
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14. Pathogenic mechanisms affecting mitochondrial DNA replication and transcription
Abstract : Mitochondria are cytoplasmic organelles fundamental to life and health. In mitochondria, energy from the food we eat is converted into adenosine triphosphate (ATP), which in turn is used as a source of chemical energy to drive a multitude of cellular reactions. READ MORE
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15. Studies of nuclear encoded mitochondrial proteins in metabolism
Abstract : Mitochondrial function is vital for human health. Inherited genetic disease can cause mitochondrial DNA (mtDNA) deficiency, disorders with generally poor prognosis. The majority of the genesinvolved in keeping a normal mitochondrial function are nuclear encoded. READ MORE