Search for dissertations about: "mitochondrial potential"

Showing result 1 - 5 of 222 swedish dissertations containing the words mitochondrial potential.

2. 1. Mitochondrial medicine. New strategies to evaluate drug toxicity and develop pharmacological protection of the cell’s powerhouse

   Author : Sarah Piel; Klinisk neurofysiologi; []
   Keywords : mitochondria; drug-induced mitochondrial toxicity; mitochondrial disease; mitochondrial medicine; drug development; succinate; methylene blue; metformin; acetaminophen; paracetamol; Kolliphor® EL;

   Abstract : Mitochondria produce the majority of the cell’s energy. Any dysfunction in, or interference with mitochondrial function can have severe consequences. And yet, it was only within the last decades that screening for potential mitochondrial toxicity was included as routine toxicity assay during early drug development. READ MORE

4. 2. Cell-Penetrating Peptides for Mitochondrial Targeting

   Author : Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. READ MORE

5. 3. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

   Author : Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

   Abstract : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. READ MORE

6. 4. Regulation of proton-coupled electron transfer in cytochrome c oxidase : The role of membrane potential, proton pathways and ATP

   Author : Markus Björck; Peter Brzezinski; Thorsten Friedrich; Stockholms universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; cytochrome c oxidase; charge transfer; membrane potential; membrane protein; mitochondria; ATP; proton pump; Biochemistry; biokemi;

   Abstract : Cytochrome c oxidase (CytcO) is the final electron acceptor of the respiratory chain. In this chain a current of electrons, derived from degradation of nutrients, along with protons, are used to reduce oxygen to water. The reaction is exergonic and the excess energy is used to pump protons across the membrane. READ MORE

7. 5. The consequences of DNA lesions for mitochondrial DNA maintenance

   Author : Josefin M. E. Forslund; Sjoerd Wanrooij; Nasim Sabouri; Erik Johansson; Claes Gustafsson; Umeå universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Mitochondria; mitochondrial DNA; DNA replication; DNA lesions; DNA polymerase γ; ribonucleotide incorporation; medicinsk biokemi; Medical Biochemistry;

   Abstract : Eukaryotic cells have their own energy-producing organelles called mitochondria. The energy is stored in the adenosine triphosphate (ATP) molecule and is produced via the oxidative phosphorylation process inside the mitochondria. Thirteen of the essential proteins required for this process are encoded on the mitochondrial DNA (mtDNA). READ MORE