Search for dissertations about: "mitochondrial protein quality control"

Showing result 1 - 5 of 12 swedish dissertations containing the words mitochondrial protein quality control.

  2. 1. The interactome of the yeast mitochondrial ribosome : Organization of mitochondrial post-transcriptional regulation, membrane protein insertion and quality control

    Author : Braulio Vargas Möller-Hergt; Martin Ott; Michal Minczuk; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondria; mitochondrial post-transcriptional regulation; mitochondrial ribosome; membrane protein insertion; mitochondrial quality control; Biochemistry; biokemi;

    Abstract : The proteins found in mitochondria originate from two different genetic systems. Most mitochondrial proteins are synthesized in the cytosol and post-translationally imported into the organelle. However, a small subset of mitochondrial proteins is encoded in an organelle-resident genome. READ MORE

  4. 2. Mitochondrial translation and its impact on protein homeostasis and aging

    Author : Tamara Suhm; Martin Ott; Aleksandra Trifunovic; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondrial ribosome; mitochondrial translation accuracy; mitochondrial communication; interorganellar communication; stress signaling; proteostasis; aging; yeast genetics; mitochondrial protein quality control; mitochondrial membrane protein insertion; Biochemistry; biokemi;

    Abstract : Besides their famous role as powerhouse of the cell, mitochondria are also involved in many signaling processes and metabolism. Therefore, it is unsurprising that mitochondria are no isolated organelles but are in constant crosstalk with other parts of the cell. READ MORE

  5. 3. Adaptation and Protein Quality Control Under Metalloid Stress

    Author : Sebastian Ibstedt; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; protein quality control; arsenite; tellurite; natural selection; Saccharomyces cerevisiae;

    Abstract : Toxic metals and metalloids are emerging as major environmental pollutants, having ecological consequences as well as being linked to a broad range of degenerative conditions in animals, plants and humans. While the toxicity of several metalloids is well established, the underlying molecular mechanisms are often not clear. READ MORE

  6. 4. Interconnectivity of mitochondrial protein biogenesis and homeostasis

    Author : Carmela Vázquez Calvo; Martin Ott; Jan Riemer; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; mitochondria; proteostasis; protein quality control; chaperones; biokemi; Biochemistry;

    Abstract : To ensure correct protein function, the cells are equipped with a tightly regulated network of chaperones that support protein folding and actively participate in protein quality control (PQC) and turnover. Due to the dual origin of the mitochondrial proteome, the cytosolic and mitochondrial PQC networks coordinate to ensure protein import and assembly in the organelle. READ MORE

  7. 5. Functional details of human HtrA2 protease studied by NMR spectroscopy

    Author : Emelie E. Aspholm; Göteborgs universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; HtrA2; nuclear magnetic resonance; protein quality control; neurodegenerative disease; apoptosis;

    Abstract : Cells rely on an array of cellular machineries in the protein quality control system (PQC) to maintain the health of the collective proteome. The HtrA family of serine proteases are found in all kingdoms of life and function in the PQC by degrading damaged and aggregated proteins as well as by acting as molecular chaperones. READ MORE