Search for dissertations about: "mitochondrial targeting"

Showing result 1 - 5 of 80 swedish dissertations containing the words mitochondrial targeting.

  1. 1. Cell-Penetrating Peptides for Mitochondrial Targeting

    Author : Carmine Pasquale Cerrato; Ülo Langel; Shana O. Kelley; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Mitochondrial targeting; cell-penetrating peptides; antioxidant activity; scavenging ability; oligonucleotide delivery; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : Mitochondria have simply been known as the cell’s powerhouse for a long time, with its vital function of producing ATP. However, substantially more attention was directed towards these organelles once they were recognized to perform several essential functions having an impact in cell biology, pharmaceutics and medicine. READ MORE

  2. 2. Cell-penetrating peptide targeting mitochondria : Design, synthesis, characterization, and biological effects

    Author : Carmine Pasquale Cerrato; Ülo Langel; Lena Mäler; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; cell-penetrating peptide; mitochondrial targeting; ROS reduction; mitochondrial membrane potential; antioxidant activity; neurokemi med molekylär neurobiologi; Neurochemistry with Molecular Neurobiology;

    Abstract : More than twenty years after the discovery of the first cell-penetrating peptide (CPP), a large number of both naturally occurring as well as engineered CPPs have been discovered. Generally, CPPs are short polycationic sequences of less than 30 amino acids that are able to translocate different cargoes into cells. READ MORE

  3. 3. Molecular studies of mitochondrial targeting peptides

    Author : Per Moberg; Ian Max Möller; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; Biokemi; biokemi; Biochemistry;

    Abstract : .... READ MORE

  4. 4. Targeting NOX2 in cancer

    Author : Ebru Aydin; Göteborgs universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; cancer; reactive oxygen species; immunotherapy; nox2; nk cells; melanoma; histamine; metastasis; leukemia; aml; cml; kras; mpd;

    Abstract : Reactive oxygen species (ROS) are short-lived, toxic derivatives of oxygen that are produced during mitochondrial respiration and by NADPH oxidases (NOX). By enzymatically generating ROS, the myeloid cell NOX2 plays a critical role in defense against bacteria and other microorganisms. READ MORE

  5. 5. Dual targeting of proteins to mitochondria and chloroplasts : Characterization of dual targeting peptides and their interaction with organellar receptors

    Author : Erika Spånning; Elzbieta Glaser; Anthony Moore; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biochemistry; biokemi;

    Abstract : Most mitochondrial and chloroplastic proteins are synthesized in the cytosol as precursor proteins with an N-terminal targeting peptide (TP), which directs them to the correct organelle. There is also a group of proteins that are dual targeted to mitochondria and chloroplasts using an ambiguous N-terminal dual targeting peptide (dTP). READ MORE