Search for dissertations about: "mitochondrial transcription factor A Tfam"

Showing result 1 - 5 of 14 swedish dissertations containing the words mitochondrial transcription factor A Tfam.

2. 1. Mitochondrial dysfunction in neurodegeneration

   Author : Mats Ekstrand; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Mitochondria; TFAM; Parkinson s disease; neurodegeneration;

   Abstract : The mitochondrial respiratory chain (RC) is responsible for providing most of the cellular energy in the form of ATP, and is also one of the main sites of reactive oxygen species (ROS) formation. The RC, consisting of five enzyme complexes in the inner mitochondrial membrane, is unique in its bipartite dependence on both nuclear and mitochondrial DNA (mtDNA). READ MORE

4. 2. The interface of mitochondrial DNA transcription and replication

   Author : Paulina Hannele Wanrooij; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mitochondria are a dynamic network of subcellular organelles that produce the majority of cellular ATP through the process of oxidative phosphorylation (OXPHOS). The components of the respiratory chain are encoded by two separate genomes, nuclear DNA and mitochondrial DNA (mtDNA), and the proper maintenance of both of these genomic entities is therefore crucial for cellular ATP levels and the survival of the cell. READ MORE

5. 3. Regulation of mitochondrial transcription and mtDNA copy number in mammals

   Author : Anja Rantanen; Karolinska Institutet; Karolinska Institutet; []
   Keywords : mtDNA; transcription factor; evolution; transmission; inheritance; expression; mitochondria; transgenic; mapping; testis-specific;

   Abstract : Functional mitochondria are essential for wellbeing of the cell and the whole organism. Gene expression from the mitochondrial genome (mtDNA) is indispensable for oxidative phosphorylation, but also for the replication of mtDNA, as the replication primers are processed from mtDNA transcripts. READ MORE

6. 4. Exercise-induced mitochondrial biogenesis : with special reference to mitochondrial transcription factors and lipin-1

   Author : Susanna E Wallman Appel; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : Mitochondrial biogenesis is one prominent adaptation to endurance training in skeletal muscle tissue. An increased mitochondrial density of the muscle fibres contributes to an enhanced aerobic capacity and thereby to improved fatigue-resistance. READ MORE

7. 5. Life without mitochondrial DNA : studies of transgenic mice

   Author : Jianming Wang; Karolinska Institutet; Karolinska Institutet; []
   Keywords : mitochondrial disease; mitochondrial DNA mtDNA ; mitochondrial transcripton factor A Tfam ; cre-loxP; conditional knockout; transgenic; mitochondrial cardiomyopathy; apoptosis;

   Abstract : Mitochondrial DNA (mtDNA) is a closed circular DNA genome that resides in the mitochondrial network. Mutations of mtDNA cause spontaneous and hereditary disorders known as mitochondrial diseases. Mitochondrial transcription factor A (Tfam) is a key factor for transcription of mtDNA in vitro. READ MORE