Search for dissertations about: "mitochondrion"
Showing result 1 - 5 of 21 swedish dissertations containing the word mitochondrion.
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1. The role of the mitochondrion in organotin-induced T-cell apoptosis
Abstract : Apoptosis plays a central role in the development and the function of the immune system. The cell death program can, however, be inappropriately activated or suppressed under pathological conditions. Several toxins have been shown to interfere with intra-thymic processes, thereby contributing to autoimmune disorders. READ MORE
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2. Molecular mechanisms of mammalian mitochondrial DNA replication and transcription
Abstract : Mitochondria are cytoplasmic organelles in eukaryotic cells, mainly devoted to the synthesis of ATP, through the Oxydative Phospshorylation System (OXPHOS). The organelle has its own genome, the mitochondrial DNA (mtDNA) that encodes for all the RNA components of the mitochondrial translation apparatus (two rRNAs and 22 tRNAs) and for 13 subunits of the OXPHOS complexes. READ MORE
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3. In silico Studies of Early Eukaryotic Evolution
Abstract : A question of great interest in evolutionary biology is how and why the eukaryotic cell evolved. Several hypotheses have been proposed, ranging from an early emergence of a primitive eukaryotic cell, to various fusion models like the hydrogen hypothesis. Within this context, relevant bacterial gene families and genomes are examined in this thesis. READ MORE
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4. Targeting apoptosis-inducing factor as a novel therapeutic strategy for preventing perinatal brain injury
Abstract : Perinatal complications such as asphyxia can cause brain injuries that are often associated with subsequent neurological deficits. The mechanisms of perinatal brain injury are not fully understood, but mitochondria play a prominent role, not only due to their central function in metabolism, but also because many proteins with apoptosisrelated functions are located in the mitochondrion. READ MORE
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5. Mitochondrial Evolution : Turning Bugs into Features
Abstract : The bacterial origin of mitochondria from an ancient endosymbiosis is now widely accepted and the mitochondrial ancestor is generally believed to belong to the bacterial subdivision α-proteobacteria. The high fraction of mitochondrial proteins encoded in the nucleus has commonly been explained with a massive transfer of genes from the genome of the ancestral mitochondrion. READ MORE
