Search for dissertations about: "mitogen-activated protein kinases"

Showing result 1 - 5 of 41 swedish dissertations containing the words mitogen-activated protein kinases.

  1. 1. Adenosine receptor signaling and the activation of mitogen-activated protein kinases

    Author : Gunnar Schulte; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : The nucleoside adenosine is present in all cells and body fluids of all living organisms; its production, both intracellularly and extracellularly, is tightly coupled to energy consumption resulting in increasing extracellular adenosine levels with increased energy consumption. Adenosine is metabolized by adenosine deaminase and adenosine kinase. READ MORE

  2. 2. Molecular targets for glucocorticoids in macrophages: cytosolic phospholipase A2 and cytokine formation

    Author : Karin Gewert; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacognosy; Pharmacological sciences; signal transduction; dexamethasone; cytosolic phospholipase A2; glucocorticoids; macrophages; protein kinase C; mitogen-activated protein kinases; TNF-alpha; IL-1beta; protein phosphatases; okadaic acid; pharmacy; toxicology; Farmakologi; farmakognosi; farmaci; toxikologi;

    Abstract : The aim of this investigation has been to study mechanisms by which glucocorticoids inhibit inflammatory processes in vitro. Type IV cytosolic 85 kDa phospholipase A2 (cPLA2) is an important modulator of inflammatory responses that is present in macrophages as well as in other cell types. READ MORE

  3. 3. Exercise effects on the mitogen-activated protein (MAP) kinase cascade in skeletal muscle

    Author : Ulrika Widegren; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; skeletal muscle; MAP kinase; contraction; acute exercise; Akt kinase; exercise intensity; signal transduction; fiber-type;

    Abstract : Exercise-induced adaptations in skeletal muscle are regulated by numerous signaling mechanisms. However, little is known about the molecular signaling mechanisms linking muscle contraction or other exercise-associated stimuli to intracellular responses in skeletal muscle. READ MORE

  4. 4. Effects of Ischaemia on the Neuroretina and Retinal Blood Vessels

    Author : Bodil Gesslein; Lund Oftalmologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; protein kinase C; tumor necrosis factor; mitogen-activated protein kinases; pig; blood vessels; mfERG; Retinal ischaemia; vascular endothelial growth factor; hypoxia-inducible factor;

    Abstract : Identification of the intracellular signal transduction pathways activated in retinal ischaemia may be important in revealing novel pharmacological targets. The retinal blood vessels are key organs in circulatory failure, and in this work the retinal vasculature was therefore examined separately from the neuroretina. READ MORE

  5. 5. Regeneration of Peripheral Nerves. The role of protein kinases, with emphasis on neurotrophic factor stimulation

    Author : Peter Wiklund; Biologiska institutionen; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; NT-4; NT-3; NGF; MAPK; PKG; PKA; PKC; nodose ganglion; DRG; conditioning effect; neurotrophic factors; protein kinases; peripheral; nerve regeneration; BDNF; GDNF; Neurology; neuropsychology; neurophysiology; Neurologi; neuropsykologi; neurofysiologi;

    Abstract : The purpose of this study was to investigate the role of protein kinases in peripheral nerve regeneration, with the use of dorsal root ganglia (DRG) and nodose ganglia explants from adult mice. The effects of neurotrophic factor stimulation and protein kinase inhibition were studied for long (days) and short term (minutes) effects. READ MORE