Search for dissertations about: "mitomycin C"

Showing result 1 - 5 of 17 swedish dissertations containing the words mitomycin C.

  2. 1. A Pharmacokinetic and Pharmacodynamic Rationale for Perioperative Cancer Chemotherapy in Patients with Peritoneal Carcinomatosis

    Author : Kurt Van der Speeten; Haile Matheme; Paul Sugarbaker; Lars Pahlman; Ingvar Syk; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Peritoneal carcinomatosis; Cytoreductive surgery; Intraperitoneal Chemotherapy; HIPEC; EPIC; Pharmacokinetics; Pharmacodynamics; Morbidity; Mortality; Surgery; Kirurgi; Kirurgi; Surgery;

    Abstract : Peritoneal carcinomatosis (PC) is a common manifestation of both gastrointestinal and gynecologic malignancies. Until recently, this condition was considered beyond curative intent treatment. Since the 1980s, new treatment strategies combining cytoreductive surgery (CRS) with perioperative intraperitoneal and intravenous chemotherapy have emerged. READ MORE

  4. 2. Enhancing membrane and secretory protein production yields in Escherichia coli

    Author : Zhe Zhang; Jan-Willem de Gier; Claes von Wachenfeldt; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; recombinant protein production; Escherichia coli; membrane protein; secretory protein; strain engineering; Biochemistry; biokemi;

    Abstract : Proteins fulfill essential functions in living cells. To produce sufficient amounts of a protein is essential to study the structure and function of a protein, or to use it for medical purposes. Escherichia coli is a Gram-negative bacterium that is widely used for recombinant protein production. READ MORE

  5. 3. Interstrand Crosslinks - Induction and repair

    Author : Daniel Vare; Dag Jenssen; Klaus Erixon; Fredrik Johansson; Marcel Tijsterman; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ICL; DNA repair; interstrand crosslink; psoralen; molekylärgenetik; Molecular Genetics;

    Abstract : DNA crosslinking agents exhibit a variety of DNA lesions, such as monoadducts, DNA-DNA interstrand or intrastrand crosslinks or DNA-protein crosslinks. Agents that produce interstrand crosslinks (ICLs) exist naturally and are widely used in chemotherapy. Therefore, it is important to understand how the lesions induced by these agents are repaired. READ MORE

  6. 4. Role of thioredoxin system in cell death caused by toxic compounds

    Author : Xu Zhang; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Thioredoxin systems, comprising Trx, TrxR and NADPH, are one of the major disulfide reductase systems, which is crucial in maintaining cellular redox balance in mammalian cells. TrxR is a selenoprotein with a Sec residue in its C-terminal active site. READ MORE

  7. 5. Oxidative stress on mammalian cell cultures during recombinant protein expression

    Author : Tomás McKenna; Carl-Fredrik Mandenius; Linköpings universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP;

    Abstract : When the cell is under stress arising from oxidation, heat, infection, toxic contamination or any other stressful condition, proteins may unfold and expose residues in their structure that under normal physiological conditions are hidden and shielded from chemical reactions.In this licentiate thesis the effects of general oxidative stress on the production of recombinant protein by mammalian cells are considered. READ MORE