Search for dissertations about: "mitotic catastrophe"

Showing result 1 - 5 of 9 swedish dissertations containing the words mitotic catastrophe.

  2. 1. Optimizing experimental radioimmunotherapy : investigating the different mechanisms behind radiation induced cell deaths

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; Umeå universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  4. 2. Experimental radioimmunotherapy and effector mechanisms

    Author : David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; Immunology; Immunologi;

    Abstract : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. READ MORE

  5. 3. Apoptosis, cellular division or mitotic catastrophe? Effects of kinase inhibition and DNa damage in lung cancer cells

    Author : Anna Therése Helén Hemström; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting in the induction of growth arrest and apoptotic cell death. READ MORE

  6. 4. DNA damage-induced cell death : the role of caspase-2

    Author : Helin Vakifahmetoglu; Karolinska Institutet; Karolinska Institutet; []
    Keywords : Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

    Abstract : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. READ MORE

  7. 5. The importance of Cyclophilins and Mps1 in cancer

    Author : Sonia Simon Serrano; Klinisk neurofysiologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Cyclophilins; liver; fibrosis; HCC; cell cycle; Mps1 and mitosis;

    Abstract : Hepatic fibrosis is a pathological response to chronic liver injuries such as chronic alcohol consumption, non-alcoholic fatty liver disease (NAFLD) or chronic viral infections. No antifibrotic compound has been approved for liver fibrosis and if the cause of the chronic injury is not solved, fibrosis can progress to cirrhosis. READ MORE