Search for dissertations about: "mitotic catastrophe"

Showing result 1 - 5 of 8 swedish dissertations containing the words mitotic catastrophe.

  1. 1. Optimizing experimental radioimmunotherapy investigating the different mechanisms behind radiation induced cell deaths

    University dissertation from Umeå : Umeå Universitet

    Author : Theres Lindgren; David Eriksson; Torgny Stigbrand; Bo Stenerlöw; [2013]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; mitotic catastrophe; senescence; cell cycle checkpoint; apoptosis; radiation; gene expression; p53; immunologi; Immunology; radiofysik; radiation physics;

    Abstract : Background. Radiation therapy is an important treatment regimen for malignant disease. Radiation therapy uses ionizing radiation to induce DNA damage in tumor cells in order to kill them. READ MORE

  2. 2. Experimental radioimmunotherapy and effector mechanisms

    University dissertation from Umeå : Klinisk mikrobiologi

    Author : David Eriksson; Torgny Stigbrand; Eva Forsell-Aronsson; [2006]
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; apoptosis; mitotic catastrophe; caspases; cell cycle disturbances; combination treatment.; NATURAL SCIENCES Biology Cell and molecular biology Immunology; NATURVETENSKAP Biologi Cell- och molekylärbiologi Immunologi;

    Abstract : Radioimmunotherapy is becoming important as a new therapeutic strategy for treatment of tumour diseases. Lately monoclonal antibodies tagged with radionuclides have demonstrated encouraging results in treatment of hematological malignancies. The progress in treatment of solid tumours using radioimmunotherapy, however, has been slow. READ MORE

  3. 3. Apoptosis, cellular division or mitotic catastrophe? : effects of kinase inhibition and DNa damage in lung cancer cells

    University dissertation from Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Author : Anna Therése Helén Hemström; Karolinska Institutet.; Karolinska Institutet.; [2007]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Non-small cell lung cancer (NSCLC) cells are generally characterized by a low response to conventional anti-cancer agents, such as DNA-damaging drugs. Treatments that induce DNA damage relies on cellular signalling resulting in the induction of growth arrest and apoptotic cell death. READ MORE

  4. 4. DNA damage-induced cell death : The role of caspase-2

    University dissertation from Stockholm : Karolinska Institutet, Institute of Enviromental Medicine

    Author : Helin Vakifahmetoglu; Karolinska Institutet.; Karolinska Institutet.; [2009]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Apoptosis; caspase-2; DNA damage; mitotic catastrophe; p53;

    Abstract : Activation of a family of cysteine proteases, called caspases, is an important event during apoptosis. In comparison to other caspases, less is known about regulatory functions of caspase-2. Previous studies from our group established caspase-2 as an essential apical regulator of apoptosis triggered by DNA damage. READ MORE

  5. 5. Insulin-like growth factor 1 receptor, novel functions and future possibilities

    University dissertation from Stockholm : Karolinska Institutet, Dept of Oncology-Pathology

    Author : Ahmed Waraky; Karolinska Institutet.; Karolinska Institutet.; [2017]
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES;

    Abstract : Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation of the receptor, leading to subsequent activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways. READ MORE