Search for dissertations about: "mitotic catastrophe"

Showing result 6 - 9 of 9 swedish dissertations containing the words mitotic catastrophe.

  2. 6. Insulin-like growth factor 1 receptor, novel functions and future possibilities

    Author : Ahmed Waraky; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Insulin like growth factor-1 receptor (IGF-1R) has been shown to be important for cancer cell growth and survival, and is often overexpressed in malignant and premalignant tissues. Ligand binding to IGF-1R induces transphosphorylation and activation of the receptor, leading to subsequent activation of the phosphatidyl inositol-3 kinase (PI3K), the mitogen-activated protein kinase (MAPK) and the 14-3-3 pathways. READ MORE

  4. 7. DNA-dependent protein kinase in normal and malignant cells : with special reference to anti-tumour agent sensitivity

    Author : Åsa Holgersson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : DNA-PK; lymphoid maturation; lymphocytic leukaemia; radiation sensitivity; drug sensitivity; drug resistance; sensitisation.;

    Abstract : The DNA-dependent protein kinase (DNA-PK) is a DNA double strand break (DSB) repair enzyme, essential for the cellular response to DNA damaging agents. DNA-PK is also of importance for lymphoid development, since it includes two processes, V(D)J recombination and lg switch recombination, during which DSBs are naturally occurring events. READ MORE

  5. 8. Signalomics : unsupervised and global strategies to explore mechanisms of radioresistence in lung cancer cells

    Author : Sara Ståhl; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : To combat lung cancer (LC) which is the number one cancer associated killer, a combination of surgery, chemotherapy, radiotherapy and targeted agents are currently used. The main subtype of LC, Non small cell lung cancer (NSCLC) unfortunately responds poorly to conventional radiotherapy (RT) for reasons yet only partly understood. READ MORE

  6. 9. Ephrin and Eph-receptor growth factor signaling in non small cell lung cancer : identification of biomarkers and therapeutic targets

    Author : Ghazal Efazat; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Non-small cell lung cancer (NSCLC) is the main subtype of lung cancer (LC) and unfortunately it responds very poorly to conventional chemo- and radiotherapy (RT). Moreover, NSCLC is often diagnosed at a stage where metastases are found and only for a limited number of NSCLC tumors targeted therapies can be used as their oncogenic drivers remains elusive. READ MORE