Search for dissertations about: "mixed model"

Showing result 1 - 5 of 885 swedish dissertations containing the words mixed model.

  2. 1. Covariate Model Building in Nonlinear Mixed Effects Models

    Author : Jakob Ribbing; E. Niclas Johnsson; Mats O. Karlsson; Janet Wade; Uppsala universitet; []
    Keywords : Pharmacokinetics Pharmacotherapy; Pharmacokinetics; Pharmacodynamics; Modeling; Covariate selection; Stepwise selection; Covariate analysis; Methodology; Model validation; Model evaluation; Type-2 diabetes; Beta-cell function; Meta analysis; Cross-validation; Least absolute shrinkage and selection operator; Pharmacometrics; ED optimization; Farmakokinetik Farmakoterapi;

    Abstract : Population pharmacokinetic-pharmacodynamic (PK-PD) models can be fitted using nonlinear mixed effects modelling (NONMEM). This is an efficient way of learning about drugs and diseases from data collected in clinical trials. READ MORE

  4. 2. Lean, Green, and Agile Design and Control of Pallet Systems

    Author : Maziar Mashaei; Chalmers tekniska högskola; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Lean structure model.; Universal model; Handling and locating pallet system; Optimization model; Energy model;

    Abstract : Pallet based automated material handling systems are main devices to transport and locate various part types in flexible production plants.To fulfill production objectives and win in the competitive environment of mass customization, proper deign and control of handling and locating pallet systems have been highly concerned. READ MORE

  5. 3. Opportunity creation as a mixed embedding process : A study of immigrant entrepreneurs in Sweden

    Author : Quang V. D. Evansluong; Caroline Wigren-Kristoferson; Marcela Ramirez-Pasillas; Monder Ram; Jönköping University; []
    Keywords : SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; SAMHÄLLSVETENSKAP; SOCIAL SCIENCES; immigrant entrepreneurship; opportunity creation; entrepreneurial opportunity; social integration; Sweden; mixed embeddedness; mixed embedding; företagsekonomi; immigrant entrepreneurship; opportunity creation; entrepreneurial opportunity; Social integration; sweden; mixed embeddedness; mixed embedding;

    Abstract : Entrepreneurial opportunities are frequently noted and addressed in the literature of immigrant entrepreneurship; however, little is known about how these entrepreneurial opportunities come into existence and how immigrant entrepreneurs create such opportunities. The purpose of this thesis is to examine why and how immigrant entrepreneurs create entrepreneurial opportunities through embedding processes in the home country and the host country. READ MORE

  6. 4. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

    Author : Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). READ MORE

  7. 5. Development and Evaluation of Nonparametric Mixed Effects Models

    Author : Paul Baverel; Mats Karlsson; Radojka Savic; Nils Hoem; Uppsala universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonparametric; model; pharmacometrics; pharmacokinetics; pharmacodynamic; imprecision; covariate analysis; parameter distribution; Statistics; computer and systems science; Statistik; data- och systemvetenskap; Pharmaceutical pharmacology; Farmaceutisk farmakologi; Biopharmaceutics; Biofarmaci; Clinical Pharmacology; Klinisk farmakologi; Computer Systems; Datorteknik; Farmakologi; Pharmacology; Statistics; Statistik;

    Abstract : A nonparametric population approach is now accessible to a more comprehensive network of modelers given its recent implementation into the popular NONMEM application, previously limited in scope by standard parametric approaches for the analysis of pharmacokinetic and pharmacodynamic data. The aim of this thesis was to assess the relative merits and downsides of nonparametric models in a nonlinear mixed effects framework in comparison with a set of parametric models developed in NONMEM based on real datasets and when applied to simple experimental settings, and to develop new diagnostic tools adapted to nonparametric models. READ MORE