Search for dissertations about: "model synthesis"

Showing result 1 - 5 of 838 swedish dissertations containing the words model synthesis.

  2. 1. Approaches to soft drug analogues of dihydrofolate reductase inhibitors : Design and synthesis

    Author : Malin Graffner Nordberg; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Pharmaceutical chemistry; soft drug; dihydrofolate reductase; synthesis; Farmaceutisk kemi; Pharmaceutical chemistry; Farmaceutisk kemi; Organic Pharmaceutical Chemistry; Organisk farmaceutisk kemi;

    Abstract : The main objective of the research described in this thesis has been the design and synthesis of inhibitors of the enzyme dihydrofolate reductase (DHFR) intended for local administration and devoid of systemic side-effects. The blocking of the enzymatic activity of DHFR is a key element in the treatment of many diseases, including cancer, bacterial and protozoal infections, and also opportunistic infections associated with AIDS (Pneumocystis carinii pneumonia, PCP). READ MORE

  4. 2. Asymmetric Synthesis of C-Glycosylated Amino Acids : Incorporation in Collagen Glycopeptides and Evaluation in a Model for Rheumatoid Arthritis

    Author : Tomas Gustafsson; Jan Kihlberg; Umeå universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Total synthesis; stereoselective synthesis; chiral glycine templates; Evan’s alkylation; asymmetric hydrogenation; alpha-amino acid synthesis; C-glycoside; rheumatoid arthritis; MHC; T cell; Organic chemistry; Organisk kemi;

    Abstract : This thesis describes stereoselective syntheses of four amino acids, three of which are C-glycosidic analogues of glycosylated amino acids. The overall goal of the project was to probe the interactions between MHC molecules, glycopeptide antigens and T cell receptors, that are essential for development of collagen induced arthritis. READ MORE

  5. 3. Model Based Coding : Initialization, Parameter Extraction and Evaluation

    Author : Zhengrong Yao; Haibo Li; Ralf Schäfer; Umeå universitet; []
    Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Signalbehandling; Model-based coding; Motion estimation; Vision based tracking; Initialization; Analysis-by-Synthesis; Texture mapping; Active tracking.; Signalbehandling; Signal processing; Signalbehandling; Signal Processing; signalbehandling;

    Abstract : This thesis covers topics relevant to model-based coding. Model-based coding is a promising very low bit rate video coding technique. The idea behind this technique is to parameterize a talking head and to extract and transmit the parameters describing facial movements. At the receiver, the parameters are used to reconstruct the talking head. READ MORE

  6. 4. Model-based coding : extraction, coding, and evaluation of face model parameters

    Author : Jörgen Ahlberg; Andrew Senior; Linköpings universitet; []
    Keywords : ;

    Abstract : This thesis deals with model-based coding of human faces for low bitrate communication. The basicidea of model-based coding is that the appearance and motion of a human face are analysed. By thisanalysis, compact parameters allowing realistic visualization of a synthetic face are extracted. READ MORE

  7. 5. Calcium-Aluminate as Biomaterial : Synthesis, Design and Evaluation

    Author : Jesper Lööf; Håkan Engqvist; Sture Hogmark; Elis Carlström; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Calcium-aluminate; Biomaterial; Dental materials; Vertebroplasty; Chemically Bonded Ceramics; Synthesis; Biomaterials; Biomaterial;

    Abstract : In this thesis different aspects of calcium-aluminate (CA) as biomaterial are presented. Calcium aluminate is a chemically bonded ceramic with inherent properties making it suitable for use as biomaterial in some applications. READ MORE