Search for dissertations about: "model-averaging"

Showing result 1 - 5 of 11 swedish dissertations containing the word model-averaging.

2. 1. Methods for handling model misspecification in pharmacometric model-based approaches for the analysis of longitudinal clinical trial data

   Author : Estelle Chasseloup; Mats Karlsson; Andrew Hooker; Karl Brendel; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; misspecification; type I error; power; accuracy; placebo; individual model averaging; IMA; likelihood ratio test; LRT; model averaging; covariate selection; mixture models; visual predictive checks; VPC; avatars; digital twins; virtual individual; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Pharmacometrics model-based analyses proved to be increasingly useful in drug discovery and development. This usefulness was made evident by the formalisation of the model-integrated drug discovery and development framework (MID3). READ MORE

4. 2. Essays on forecasting and Bayesian model averaging

   Author : Jana Eklund; Handelshögskolan i Stockholm; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : This thesis, which consists of four chapters, focuses on forecasting in a data-rich environment and related computational issues. Chapter 1, “An embarrassment of riches: Forecasting using large panels” explores the idea of combining forecasts from various indicator models by using Bayesian model averaging (BMA) and compares the predictive performance of BMA with predictive performance of factor models. READ MORE

5. 3. Bayesian Phylogenetics and the Evolution of Gall Wasps

   Author : Johan A. A. Nylander; Fredrik Ronquist; Sydney A. Cameron; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; Biology; Bayesian analysis; Bayes factors; Cynipidae; gall wasps; MCMC; model averaging; model selection; phylogeny; total evidence; Biologi; Biology; Biologi;

   Abstract : This thesis concerns the phylogenetic relationships and the evolution of the gall-inducing wasps belonging to the family Cynipidae. Several previous studies have used morphological data to reconstruct the evolution of the family. READ MORE

6. 4. Improved Methods for Pharmacometric Model-Based Decision-Making in Clinical Drug Development

   Author : Anne-Gaëlle Dosne; Mats O. Karlsson; Rik Schoemaker; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; nonlinear mixed-effects models; confirmatory trials; residual error modeling; parameter uncertainty; sampling importance resampling; model-averaging; Farmaceutisk vetenskap; Pharmaceutical Science;

   Abstract : Pharmacometric model-based analysis using nonlinear mixed-effects models (NLMEM) has to date mainly been applied to learning activities in drug development. However, such analyses can also serve as the primary analysis in confirmatory studies, which is expected to bring higher power than traditional analysis methods, among other advantages. READ MORE

7. 5. Model Selection and Sparse Modeling

   Author : Yngve Selén; Peter Stoica; Jean-Jacques Fuchs; Uppsala universitet; []
   Keywords : TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; model selection; model order selection; model averaging; nested models; sparse models; Bayesian inference; MMSE estimation; MAP estimation; ML estimation; AIC; BIC; GIC; RAKE receivers; pulse compression; radar; linear models; linear regression models; Signal processing; Signalbehandling;

   Abstract : Parametric signal models are used in a multitude of signal processing applications. This thesis deals with signals for which there are many candidate models, and it is not a priori known which model is the most appropriate one. READ MORE