Search for dissertations about: "model-based compartmental analysis"

Found 4 swedish dissertations containing the words model-based compartmental analysis.

  2. 1. Computational Modelling and Topological Analysis of the striatal microcircuitry in health and Parkinson's disease

    Author : Ilaria Carannante; Jeanette Hellgren Kotaleski; Alexander Kozlov; Sean Hill; KTH; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; Datalogi; Computer Science;

    Abstract : The basal ganglia are evolutionary conserved nuclei located at the base of the forebrain. They are a central hub in the control of motion and their dysfunctions lead to a variety of movement related disorders, including Parkinson's disease (PD).The largest nucleus and main input stage of the basal ganglia is the striatum. READ MORE

  4. 2. Studies on the effects of 2,3,7,8-tetrachlorodibenzo-p-dioxin on vitamin A homeostasis

    Author : Charlotte Nilsson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : TCDD; dioxin; vitamin A; retinoic acid; lecithin:retinol acyltransferase; retinyl ester hydrolysis; retinol-binding protein; kidney; lymph; stellate cell; kinetics; model-based compartmental analysis;

    Abstract : Vitamin A (retinoids) is needed for normal vision, growth, reproduction, cell differentiation, embryonic development, and immune function. Retinoids exert their functions in the same way as classical hormones, as transcription factors acting via nuclear receptors. READ MORE

  5. 3. Pharmacometric Models to Improve Treatment of Tuberculosis

    Author : Elin M Svensson; Mats O Karlsson; Maria C Kjellsson; Ulrika S H Simonsson; N. L’Ntshotsholé (Shasha) Jumbe; Uppsala universitet; []
    Keywords : pharmacokinetics; pharmacodynamics; population approach; nonlinear mixed-effects models; multidrug-resistant tuberculosis; bedaquiline; antiretroviral; drug-drug interactions; time-to-event; albumin; Klinisk farmakologi; Clinical Pharmacology;

    Abstract : Tuberculosis (TB) is the world’s most deadly infectious disease and causes enormous public health problems. The comorbidity with HIV and the rise of multidrug-resistant TB strains impede successful therapy through drug-drug interactions and the lack of efficient second-line treatments. READ MORE

  6. 4. Garnishing the smorgasbord of pharmacometric methods

    Author : Henrik Bjugård Nyberg; Andrew Hooker; Johannes Schropp; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; pharmacometrics; pharmacokinetics; saddle points; nonidentifiability; modelling and simulation; tuberculosis; ethionamide; bioequivalence; model-integrated evidence; Farmaceutisk vetenskap; Pharmaceutical Science;

    Abstract : The smorgasbord of methods that we use within the field of pharmacometrics has developed steadily over several decades and is now a well-laid-out buffet. This thesis adds some garnish to the table in the form of small improvements to the handling of certain problems. READ MORE