Search for dissertations about: "model-based development"

Showing result 16 - 20 of 330 swedish dissertations containing the words model-based development.

2. 16. A Framework for Cyber-physical System Tool-chain Development : A Service-oriented and Model-based Systems Engineering Approach

   Author : Lu Jinzhi; Martin Törngren; Vangheluwe Hans; KTH; []
   Keywords : Cyber-physical system development; Model-based systems engineering; Tool-chain; Domain-specific modeling; Tool-integration; Co-simulation; Systems thinking; Industriella informations- och styrsystem; Industrial Information and Control Systems;

   Abstract : The development of complex Cyber-physical Systems (CPS) requires tight interactions of projects, system components, stakeholders, data and models. These models and data support component design, which are implemented by various engineering tools used by stakeholders. Effective tool integration thus relies on development of tool-chains. READ MORE

4. 17. Model-Based Optimization of Clinical Trial Designs

   Author : Camille Vong; Mats O. Karlsson; Andrew C. Hooker; Lena E. Friberg; Marylore Chenel; Oliver Sander; Uppsala universitet; []
   Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; nonlinear mixed-effects models; pharmacometrics; likelihood ratio test; NONMEM; power; sample size; study design; proof-of-concept; dose-finding; population optimal design; LOQ; BQL data; neutropenia; docetaxel; myelosuppression; thrombocytopenia; MTD; Bayesian methods; 3 3 algorithm; dose escalation study; Pharmaceutical Science; Farmaceutisk vetenskap;

   Abstract : General attrition rates in drug development pipeline have been recognized as a necessity to shift gears towards new methodologies that allow earlier and correct decisions, and the optimal use of all information accrued throughout the process. The quantitative science of pharmacometrics using pharmacokinetic-pharmacodynamic models was identified as one of the strategies core to this renaissance. READ MORE

5. 18. Security in Embedded Systems : A Model-Based Approach with Risk Metrics

   Author : Maria Vasilevskaya; Simin Nadjm-Tehrani; Ketil Stølen; Linköpings universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : The increasing prevalence of embedded devices and a boost in sophisticated attacks against them make embedded system security an intricate and pressing issue. New approaches to support the development of security-enhanced systems need to be explored. READ MORE

6. 19. Design and Optimization under Uncertainties : A Simulation and Surrogate Model Based Approach

   Author : Johan Persson; Johan Ölvander; David Aspenberg; Linköpings universitet; []
   Keywords : ;

   Abstract : This thesis deals with development of complex products via modeling and simulation, and especially the use of surrogate models to decrease the computational efforts when probabilistic optimizations are performed. Many methods that can be used to perform probabilistic optimizations exist and this thesis strives to present and demonstrate the capabilities of a few of them. READ MORE

7. 20. Integrated information management in complex product development

   Author : Diana Malvius; Margareta Norell Bergendahl; Chris A. McMahon; KTH; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; TEKNIK OCH TEKNOLOGIER; ENGINEERING AND TECHNOLOGY; Information management; information systems; integrated product development; systems engineering; innovation management; PLM; model-based development; Information technology; Informationsteknik; Construction engineering; Konstruktionsteknik;

   Abstract : Where do companies begin their efforts when trying to improve information management in product development? In large companies involving many people, multiple processes and highly technological products several factors have an impact on efficiency. Interdisciplinary integration and structured information are two overall proposed key factors that have been identified as important to obtain efficient information management. READ MORE