Search for dissertations about: "moiety"

Showing result 21 - 25 of 243 swedish dissertations containing the word moiety.

  2. 21. Design and Synthesis of Aspartic and Serine Protease Inhibitors : Targeting the BACE-1 and the HCV NS3 Protease

    Author : Fredrik Wångsell; Mats Larhed; Jari Yli-Kauhaluoma; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Alzheimer s disease; BACE-1; transition state mimetic; tertiary hydroxyl group; hydroxyethylene; statine; hydroxyethylamine; hepatitis C; HCV NS3; bioisostere; protease inhibitor.; Pharmaceutical chemistry; Läkemedelskemi; Medicinal Chemistry; Läkemedelskemi;

    Abstract : This thesis describes work done to design and synthesize protease inhibitors, with the intention of developing therapeutic agents for Alzheimer’s disease (AD) and the chronic liver condition caused by infection of the hepatitis C virus (HCV). AD is the most common form of dementia, and HCV infection is the primary reason for liver transplantation in industrialized countries. READ MORE

  4. 22. Nickel and iridium pincer complexes with saturated frameworks - synthesis and reactivity

    Author : Klara Jonasson; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; PCP complexes; aliphatic pincer ligands; coordination; cyclometallation; iridium; nickel; organometallic synthesis; CO2 activation; catalysis;

    Abstract : As the tridentate chelate complexes referred to as pincer complexes have expanded their scope as homogeneous catalysts, there is an increased interest in electronic and steric fine-tuning of such complexes. One accessible variable in this aspect is the hybridisation of any coordinated carbon atoms. READ MORE

  5. 23. Structural biology of carbohydrate transfer and modification in natural product biosynthesis

    Author : Magnus Claesson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Certain organisms, can during periods of limited resources, adapt their metabolism to enable biosynthesis of secondary metabolites, compounds that increase competitiveness and chances of survival. The subjects of this thesis are enzymes acting on carbohydrate substrates during secondary metabolism. READ MORE

  6. 24. Anti-gene oligonucleotides : DNA binding and therapeutic application

    Author : Tea Umek; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The field of nucleic acid therapeutics has in the last decade experienced substantial growth. This is evident from a multitude of new publications, an increasing number of clinical trials and several approved therapeutics on the market. READ MORE

  7. 25. Unveiling biomacromolecule interactions-NMR and optical spectroscopy studies on ligand binding to DNA and lysozyme

    Author : Lisha Wu; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ruthenium compounds; intercalation; Hoechst 33258; CD; fluorescence; DNA; structure rearrangements.; lysozyme; NMR;

    Abstract : Studies on intercalation of bulky binuclear ruthenium compounds into DNA have attracted attention due to their slow dissociation rate and sequence selectivity. Previous results showed that dumb-bell shaped molecules of the type [μ-(bidppz)(L)4Ru2]4+, L=phenanthroline or bipyridine, bind rapidly on the surface of DNA prior to intercalation. READ MORE