Search for dissertations about: "molecular epidemiology of HIV-1"

Showing result 1 - 5 of 9 swedish dissertations containing the words molecular epidemiology of HIV-1.

  2. 1. HIV-1 evolution, disease progression and molecular epidemiology of HIV-1 single and HIV-1 and HIV-2 dual-infected individuals in Guinea-Bissau

    Author : Joakim Esbjörnsson; Institutionen för experimentell medicinsk vetenskap; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HIV-1; HIV-2; Guinea-Bissau; subtype; disease progression; evolution; coreceptor tropism; CXCR4; gp120; V1-V3; CD4%; CD8%; soluble immune markers;

    Abstract : The two genetically related human lentiviruses known today, HIV-1 (which is pandemic) and HIV-2 (which mainly is confined to West Africa), are the causative agents of AIDS. Progressive immune dysfunction and AIDS develop in most cases of untreated HIV-1 infection, but only in approximately 25-30% of HIV-2 infected individuals. READ MORE

  4. 2. Significance of HIV-1 genetic subtypes

    Author : Annette Alaeus; Karolinska Institutet; Karolinska Institutet; []
    Keywords : HIV-1; genetic subtypes; molecular epidemiology; disease progression; CD4 cell decline; plasma RNA levels; chemokine coreceptor usage;

    Abstract : The human immunodeficiency virus type 1 (HIV-1) displays high genetic variability. Phylogenetic studies have shown that a majority of HIV-1 sequences cluster into one large group called M (major), whereas a few are clearly distinct, group O (outlier) and group N (non-M-non-O). READ MORE

  5. 3. Genetic variation of HIV-1 : molecular epidemiology and viral evolution

    Author : Thomas Leitner; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : HIV-1 displays a very high genetic variability. The evolutionary process of the virus generates a nucleotide substitution rate which is approximately one million times faster than that of higher organisms. This remarkable rate in combination with a half-life of six to eight hours, gives HIV-1 an enormous potential of genetic adaptation. READ MORE

  6. 4. HIV-1 drug resistance and molecular epidemiology in Honduras

    Author : Wendy Murillo; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The high genetic diversity and rapid evolution of HIV-1 poses a challenge to the worldwide prevention and treatment programs. Effective antiretroviral treatment has significantly improved the quality of life for HIV-infected patients. READ MORE

  7. 5. Antiretroviral treatment outcome and molecular epidemiology of HIV-1 subtype C drug resistance in Ethiopia

    Author : Nigus Fikrie Telele; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Over the last decade, antiretroviral therapy (ART) has been rolled out in Ethiopia at a large scale. However, the outcome and aspects of drug resistance have been poorly studied at the national level. Also, the epidemic has been reported to be dominated by HIV-1 subtype C (HIV-1C), but this has not been verified at a nationwide level. READ MORE