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Showing result 1 - 5 of 41 swedish dissertations matching the above criteria.

  2. 1. Studies of DNA repair strategies in response to complex DNA damages

    Author : Ainars Bajinskis; Mats Harms-Ringdahl; Bo Stenerlöw; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; ionizing radiation; complex DNA damage; indirect effect of radiation; dimethyl sulfoxide; molekylärgenetik; Molecular Genetics;

    Abstract : The main aim of this thesis was to study the role of the indirect actions of γ-rays and α-particles on the complexity of primary DNA damages and the repair fidelity of major DNA repair pathways: non-homologous end joining (NHEJ), homologous recombination repair (HRR) and base excision repair (BER). The complexity of radiation-induced damages increases and the proximity between damages decreases with increasing LET due to formation of ionization clusters along the particle track. READ MORE

  4. 2. Studies on the functional interaction of translation initiation factor IF1 with ribosomal RNA

    Author : Jaroslav Belotserkovsky; Leif Isaksson; Diarmaid Hughes; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Escherichia coli; ribosome; rRNA mutation; molekylärgenetik; Molecular Genetics;

    Abstract : Translation initiation factor IF1 is a small, essential and ubiquitous protein factor encoded by a single infA gene in bacteria. Although several important functions have been attributed to IF1, the precise reason for its indispensability is yet to be defined. READ MORE

  5. 3. Site-specific recombination in P2-like coliphages

    Author : Carlos Cardoso Palacios; Elisabeth Haggård-Ljungquist; Didier Mazel; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Genetics; Genetik; molekylärgenetik; Molecular Genetics;

    Abstract : The scope of these studies has been to investigate the site-specific recombination systems of P2-like coliphages, both in an evolutionary perspective by a comparative analysis of related phages as well as in a functional perspective. Surveys of P2-like phages in Escherichia coli isolated from nature reveal the existence of seven discrete immunity classes and three integration sites, one of them previously unknown. READ MORE

  6. 4. Studies of bioactive lipids in cancer

    Author : Vicky Chatzakos; Petra De Verdier; Jenny Flygare; Åke Nilsson; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Lipids; Sphingolipids; N-acyl amino acids; cancer; molekylärgenetik; Molecular Genetics;

    Abstract : Lipids are a broad class of molecules that, besides being a major form of energy storage and components of cell membranes, act as bioactive signalling molecules. N-acyl taurines are structurally related to endocannabinoids that are known to exert antiproliferative actions in a variety of cancer cells. READ MORE

  7. 5. Function and regulation of release factor one in Escherichia coli

    Author : Ann Dahlgren; Monica Rydén Aulin; Thomas Elliott; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; molekylärgenetik; Microbiology; Mikrobiologi;

    Abstract : During translation termination the stop codons UAA and UAG are recognised by release factor one (RF1). RF1 binds to the ribosome and mediates the hydrolysis of the nascent peptide from the peptidyl-tRNA. In this process, RF1 interacts directly or indirectly with several ribosomal proteins (r-proteins). READ MORE