Search for dissertations about: "mono-"

Showing result 21 - 25 of 320 swedish dissertations containing the word mono-.

  2. 21. Microwave spectroscopical investigations of some halogenated butadienes

    Author : Per Cederbalk; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Spektralanalys;

    Abstract : This thesis deals with microwave spectroscopical investigations of four mono-halogenated 1,3-butadienes. Two of the investigations are mainly concerned with the elucidation of complete molecular structures using the isotopical substitution method, whereas the other two deal chiefly with the determination of molecular charge distributions. READ MORE

  4. 22. Making Analogues of Tröger's Base – Fused oligomers, endo/exo isomers and twisted amides

    Author : Josep Artacho Ruiz; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES;

    Abstract : The centenarian Tröger’s base (TB) was envisaged as scaffold for the construction of tubular-shaped cleft molecules due to its the remarkable structural properties. This endeavor started with the synthesis of the three possible diastereomers of a linear symmetrically fused tris-TB analogue, the anti-anti, the syn-syn, and the syn-anti. READ MORE

  5. 23. Experimental combination therapy of brain cancer cell models

    Author : Ana-Maria Marino; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : Epigenetic alterations and aberrant expression of genes controlling epigenetic mechanisms have been identified in several cancers, including medulloblastoma and glioma, the most common primary brain tumors in children and adults, respectively. We have been investigating if combination therapy using histone deacetylase inhibitors (HDACi) and receptor tyrosine kinase inhibitors (RTKi) will enhance glioblastoma and medulloblastoma cell killing. READ MORE

  6. 24. Improving Tröger's Base Chemistry : Developing the Chemistry of Tröger's base

    Author : Sami Dawaigher; Centrum för analys och syntes; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Tröger’s base; Host Guest Chemistry; Metalation; Computational Chemistry; Supramolecular Chemistry;

    Abstract : The Tröger’s base framework has been implemented in two different receptors. The first of these receptors, incorporating two 18-crown-6 moities, was used as a host in a binding study together with a sieries of bisammonium salts that yielded different binding constants that were then used as a benchmark to compare different computational methods (Molecular Mechanics (MM) and Density Functional Theory (DFT)) in predicting the correct results where the MM methods proved more effective. READ MORE

  7. 25. Synthesis of inositol phosphoglycans and analogues thereof

    Author : Katinka Ruda; JS Brimacombe; Stockholms universitet; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; Organic chemistry; Organisk kemi; Organic Chemistry; organisk kemi;

    Abstract : This thesis describes the synthesis of inositol phosphoglycans (IPG) corresponding to glycosyl-phosphatidylinositol (GPI) anchors found on the cell surface of the parasite Leishmania. Synthesis of an IPG which is a putative second messenger for insulin, and of analogues thereof is also discussed. READ MORE