Search for dissertations about: "monoclonal antibodies production"

Showing result 1 - 5 of 77 swedish dissertations containing the words monoclonal antibodies production.

  2. 1. Exploring Monoclonal Antibody Action Against the Group A Streptococcal M Protein

    Author : Sebastian Wrighton; Infektionsmedicin; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; group A streptococcus; Streptococcus pyogenes; fibronectin; phagocytosis; innate immunity; antibodies; adaptive immunity;

    Abstract : Group A Streptococcus (GAS) is a significant human pathogen that has developed multipleimmune evasion mechanisms to counter the host immune response. One of these mechanisms involvesthe production of the M protein, which, amongst other things, acts as an anti-phagocytic factor and canbind host proteins. READ MORE

  4. 2. Amyloid-β Protofibrils in Alzheimer´s Disease : Focus on Antibodies, Inflammation and Astrocytes

    Author : Sofia Söllvander; Lars Lannfelt; Anna Erlandsson; Frida Ekholm-Pettersson; Linda Söderberg; Pär Gellerfors; Martin Hallbeck; Uppsala universitet; []
    Keywords : Alzheimer s Disease; Amyloid-beta; Protofibrils; ELISA; ELISpot; Astrocyte; Monoclonal Antibody; Immunofluorescence; Medicinsk vetenskap; Medical Science;

    Abstract : Soluble amyloid-beta (Aβ) aggregates, including Aβ protofibrils, play a central role in Alzheimer’s disease (AD) and constitute a potential diagnostic biomarker and a therapeutic target. Aβ protofibrils promote synapse dysfunction and neurodegeneration, but the mechanisms behind these effects remain unclear. READ MORE

  5. 3. Expression of Ig genes. Regulation of transcription and production of human antibodies

    Author : Christina Furebring; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; Bioteknik; Biotechnology; human antibodies; immunoglobulin gene expression; 3 enhancer; serology; transplantation; Immunologi; serologi;

    Abstract : During B lymphocyte development, the transcriptional activity of the IgH locus is subject to spatial and temporal changes. The 3' enhancer (3'E) has been suggested to play an important role in regulation of immunoglobulin gene expression late in B cell development. READ MORE

  6. 4. Functional studies of anti-gpi monoclonal antibodies and anti-citrullinated protein antibodies (ACPAS)

    Author : Taotao Li; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : RA is an autoimmune disease that primarily impacts joints throughout the body. The disease can result in pain, stiffness, and reduced mobility. It is a chronic disease, meaning that it lasts a long time and can worsen over time if left untreated. READ MORE

  7. 5. Expression and interaction studies of recombinant human monoclonal antibodies

    Author : Daniel X Johansson; Karolinska Institutet; Karolinska Institutet; []
    Keywords : ;

    Abstract : The highly specific binding characteristics of monoclonal antibodies (mAbs) have made them one of the most useful tools in the fields of research and biotechnology where they provide the basis for a large number of diagnostic and technical assays. In recent years, with the advent of techniques to generate fully human antibodies, mAbs have also emerged as a new important class of therapeutics. READ MORE