Search for dissertations about: "monoclonal antibodies"

Showing result 21 - 25 of 319 swedish dissertations containing the words monoclonal antibodies.

  2. 21. Human IgE - What We Can Learn from Repertoire Studies and How We Can Use Them as Tools

    Author : Mattias Levin; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Allergy; antibodies; IgE; transcriptome analysis; immunotherapy; molecular biology;

    Abstract : Antibodies of the IgE isotype play a key role as the allergen recognizer in allergic disease, which today affects as much as a third of the population in the industrialized parts of the world. Despite this crucial role of IgE, our knowledge of IgE repertoires and how we can utilize the information hidden in monoclonal IgE to improve the quality of life of allergic patients, is limited. READ MORE

  4. 22. Recombinant antibodies and tumor targeting

    Author : Ali Sheikholvaezin; Torgny Stigbrand; Gregory P Adams; Umeå universitet; []
    Keywords : immunologi; Immunology;

    Abstract : Different antibody derived constructs are rapidly advancing as putative tools for treatment of malignant diseases. Antibody engineering has added significant new technologies to modify size, affinities, solubility, stability and biodistribution properties for immunoconjugates. READ MORE

  5. 23. Astatine-211 and Iodine Conjugates: Radiohalogenation and Preclinical Pharmacokinetics for Targeted and Pretargeted Radioimmunotherapy

    Author : Sture Lindegren; Chalmers tekniska högskola; []
    Keywords : NATURVETENSKAP; NATURAL SCIENCES; radioimmunotherapy; antibodies; dry-distillation; radiohalogenation; pretargeting; iodine; astatine-211;

    Abstract : Endoradiotherapy using labelled tumour specific-monoclonal antibodies in the therapy of malignant disease is a therapeutic modality that is coming of age. While clearly defined tumours can be treated with surgery and/or chemotherapy, occult metastases requires adjuvant systemic treatment, e.g. READ MORE

  6. 24. The CD40 Receptor - Target,Tool and Technology

    Author : Peter Ellmark; Institutionen för immunteknologi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Immunology; serology; transplantation; Immunologi; serologi; SPIRE; mammalian; library; cDNA; selection; receptor revision; phage display; scFv; human; CD40; antibodies;

    Abstract : CD40 is a cell surface receptor of pivotal importance that is expressed on several of the cells in the immune system. It is critical for many important events, such as T cell dependent B cell activation, isotype switching, somatic mutation and generation of B cell memory. READ MORE

  7. 25. Targeting molecules for diagnostics of Head and Neck squamous cell carcinoma

    Author : Anna-Karin Haylock; Marika Nestor; Göran Laurell; Matti Anniko; Katrine Riklund; Uppsala universitet; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; HNSCC; CD44v6; radio-immunodiagnosis; immuno-PET; tumor targeting; antibodies; antibody fragments; Oto-Rhino-Laryngology; Oto-rhino-laryngologi;

    Abstract : To personalize treatment for cancer, correct staging of the primary tumor, nodal disease and metastatic disease is of essence. By targeting tumor specific receptors with radiolabeled antibodies, specificity and accuracy of imaging may be improved. READ MORE