Search for dissertations about: "morphogen"

Showing result 1 - 5 of 20 swedish dissertations containing the word morphogen.

  1. 1. Functions of Heparan Sulfate During Mouse Development : Studies of Mice with Genetically Altered Heparan Sulfate Biosynthesis

    Author : Maria Ringvall; Lena Kjellén; Erik Forsberg; Ulf Lindahl; Erika Gustafsson; Uppsala universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Developmental biology; embryonic development; gene targeting; lung development; ossification; heparan sulfate; heparin; N-deacetylase N-sulfaotransferase; NDST; proteoglycan; morphogen; biosynthesis; Utvecklingsbiologi; Developmental biology; Utvecklingsbiologi;

    Abstract : Heparan sulfate (HS) is a ubiquitous polysaccharide on the cell surface and in the extracellular matrix. HS is an important actor in the regulation of cell signaling, especially in the developing embryo. READ MORE

  2. 2. Morphogen interpretation in the developing nervous system

    Author : Sanja Kurdija; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Development of the central nervous system relies on the generation of specialized cell types in a tightly controlled spatial and temporal order from neural progenitor cells. Morphogen molecules, secreted by defined sources, spatially organize neural progenitors by inducing discrete expression patterns of cell fate determinant genes in a concentration-dependent manner. READ MORE

  3. 3. Transcriptional and epigenetic control of gene expression in embryo development

    Author : Ann Boija; Mattias Mannervik; Jerry L. Workman; Stockholms universitet; []
    Keywords : NATURAL SCIENCES; NATURVETENSKAP; NATURVETENSKAP; NATURAL SCIENCES; Epigenetics; Cell specification; Drosophila embryo; Dorsal morphogen; CBP p300; Gene regulation; Chromatin; Promoter proximal Pol II pausing; utvecklingsbiologi; Developmental Biology;

    Abstract : During cell specification, temporal and spatially restricted gene expression programs are set up, forming different cell types and ultimately a multicellular organism. In this thesis, we have studied the molecular mechanisms by which sequence specific transcription factors and coactivators regulate RNA polymerase II (Pol II) transcription to establish specific gene expression programs and what epigenetic patterns that follows. READ MORE

  4. 4. Regulation of morphogen signalling during neural patterning in the Xenopus embryo

    Author : Hooi Min Tan Grahn; Avdelningen för molekylärmedicin och genterapi; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Suppressor-of-fused; Gli; β-Catenin; Neural; Xenopus; FGF; Signalling; HtrA1; RDH10; Retinol dehydrogenase; Retinoic acid; Spemann s organizer; Induction; Gradient;

    Abstract : Morphogens such as Hedghog, Wnt, FGF, and retinoic acid are important signals whose concentrations need to be tightly regulated in the vertebrate embryo to ensure body axis development and formation of the central nervous system. We first show that the intracellular cytoplasmic protein XSufu acts as a dual regulator of Hedgehog (Hh) and Wnt signals during neural induction and patterning in the Xenopus embryo. READ MORE

  5. 5. Mechanisms of cell diversification

    Author : Christopher Winston Uhde; Karolinska Institutet; Karolinska Institutet; []
    Keywords : MEDICAL AND HEALTH SCIENCES; MEDICIN OCH HÄLSOVETENSKAP;

    Abstract : Cell identity and function is determined by the intrinsic wiring of the gene regulatory network that endows progenitors with the competence to respond appropriately to extrinsic cues in a spatiotemporally-dependent manner. One such class of cues, morphogens, instruct cells in their identity by virtue of a concentration gradient, but how this is interpreted at gene regulatory levels to result in sharp and robust boundaries of gene expression is poorly understood. READ MORE