Search for dissertations about: "morpholino knockdown"

Showing result 1 - 5 of 8 swedish dissertations containing the words morpholino knockdown.

2. 1. Translational research of the quaking gene : Focusing on the conjunction between development and disease

   Author : Bryn Farnsworth; Lina Emilsson; Roman Chrast; Uppsala universitet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES; NATURVETENSKAP; NATURAL SCIENCES; MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; QKI; glia; oligodendrocyte; Alzheimer s; schizophrenia; zebrafish; statistics; morpholino; Biologi med inriktning mot evolutionär organismbiologi; Biology with specialization in Evolutionary Organismal Biology;

   Abstract : Quaking (QKI) is an RNA binding protein involved in the post-transcriptional regulation of gene expression. Originally identified as the cause of hypomyelination in a mouse mutant, it has since been consistently implicated in a wide range of neurological diseases. READ MORE

4. 2. Functional genomics of vascular endothelial cells

   Author : Elisabet Wallgard; Karolinska Institutet; Karolinska Institutet; []
   Keywords : Vasculature; endothelial cells; angiogenesis; vascular endothelial growth factor VEGF ; Notch; transcriptome; genomics; microarray; tumor; retina; morpholino knockdown;

   Abstract : Angiogenesis, the formation of new blood vessels from preexisting ones, is a process involved in normal development as well as in several pathological conditions, such as cancer, ischemic heart disease, wound healing and certain retinal complications. Antiangiogenic targeting is therefore a promising new therapeutic principle. READ MORE

5. 3. Characterization of novel genes of importance for renal glomerular function and disease

   Author : Ásmundur Oddsson; Karolinska Institutet; Karolinska Institutet; []
   Keywords : kidney glomerulus;

   Abstract : Glomerular kidney diseases are a major health care burden. The glomerular filtration barrier consists of three layers: the slit diaphragm that bridges the interlocking foot pro- cesses of the podocytes, the glomerular basement membrane and fenestrated endothelial cells. READ MORE

6. 4. Functional role of cytoskeletal, contractile and regulatory proteins in muscle disease

   Author : Mei Li; Karolinska Institutet; Karolinska Institutet; []
   Keywords : ;

   Abstract : The function of skeletal muscle is an essential component of animal physiology and daily life. Hereditary muscle diseases are comparatively rare in humans, but often very severe. The disease causes are heterogeneous, defects in nerves, intracellular components, structural proteins and the contractile apparatus can be involved. READ MORE

7. 5. Teleost retina : a model for study neurogenesis and angiogenesis

   Author : Satish Srinivas Kitambi; Agneta Mode; Jarema Malicki; Per Kylster; Thomas Burglin; Finn Hallböök; Södertörns högskola; Karolinska Institutet; Karolinska Institutet; []
   Keywords : NATURVETENSKAP; NATURAL SCIENCES;

   Abstract : Teleost models, zebrafish and medaka have become popular models to study various aspects of developmental biology and genetics. The rapid embryonic development, transparent embryos and the availability of many mutants for various developmental and molecular pathways contribute to the usefulness of these models. READ MORE