Search for dissertations about: "motif search"
Showing result 16 - 20 of 23 swedish dissertations containing the words motif search.
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16. Structure and Dynamics of the Hepatitis B Virus Encapsidation Signal Revealed by NMR Spectroscopy
Abstract : This thesis describes the study of the three-dimensional structure and dynamics of the hepatitis B virus (HBV) encapsidation signal, epsilon, by means of nuclear magnetic resonance (NMR) and mutational data. HBV replicates by reverse transcription of an RNA pregenome into the viral DNA genome, which becomes enclosed in viral particles (encapsidation). READ MORE
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17. Identification and characterisation of the novel mammalian gene family Elovl
Abstract : Comparative analysis is one of the foremost tools in biology. The most common comparative method is sequence alignment, which can be performed in many ways. By using any sort of alignments, competing sequences are evaluated by scoring schemes for estimating similarity. READ MORE
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18. Crystallographic studies on redox enzymes containing the thioredoxin fold
Abstract : Three-dimensional structures of two redox enzymes, glutathione peroxidase from human plasma and a protein disulfide oxidoreductase from the archaeon Pyrococcus furiosus, have been determined by X-ray crystallography. Glutathione peroxidases constitute a family of antioxidant seleno-enzymes that catalyze the reduction of a variety of hydroperoxides. READ MORE
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19. Exploring Palladium-Mediated 11C/12C-Carbonylation Reactions : PET Tracer Development Targeting the Vesicular Acetylcholine Transporter
Abstract : The work presented herein describes the utilization and exploration of palladium-mediated incorporations of carbon monoxide and/or [11C]carbon monoxide into compounds and structural motifs with biological relevance.The first part of the thesis describes the design, synthesis and 11C-labeling of prospective PET tracers for the vesicular acetylcholine transporter (VAChT), a target affected in several neurodegenerative diseases. READ MORE
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20. Molecular basis and pharmacological implications of Alzheimer amyloid ß-peptide fibril formation
Abstract : Alzheimer's disease is a progressive neurodegenerative disease, mostly affecting elderly. The invariable deposition of protease-resistant fibrils of Alzheimer amyloid ß-peptide (Aß) in the parenchyma and blood vessels of the brain is a central event. READ MORE