Search for dissertations about: "mouse Medicine human and vertebrates Multiple Sclerosis Blood-brain barrier MMP Dystroglycan EAE Medicin människa och djur"

Found 1 swedish dissertation containing the words mouse Medicine human and vertebrates Multiple Sclerosis Blood-brain barrier MMP Dystroglycan EAE Medicin människa och djur.

  2. 1. The Role of Matrix Metalloproteinases in Leukocyte Transmigration in Murine Experimental Autoimmune Encephalomyelitis

    Author : Smriti Agrawal; Tumörmikromiljö; []
    Keywords : MEDICIN OCH HÄLSOVETENSKAP; MEDICAL AND HEALTH SCIENCES; Medicine human and vertebrates ; mouse; Multiple Sclerosis; Blood-brain barrier; MMP; Dystroglycan; EAE; Medicin människa och djur ;

    Abstract : Murine experimental autoimmune encephalomyelitis (EAE) is a commonly used model in the investigation of the human disease multiple sclerosis (MS), a debilitating inflammatory disease of the central nervous system (CNS). MS and EAE involve multiple steps, primarily, auto-antigenic leukocyte (mainly T-cells and macrophages) crossing the blood-brain barrier and later their invasion into the CNS where they degrade myelin basic protein, eventually resulting in axonal degradation and CNS inflammation. READ MORE